Words similar to crotalid
Example sentences for: crotalid
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The in vitro myotoxicity of the crotalid venoms venoms ( Bothrops jararaca , Bothrops jararacussu and Lachesis muta ) and myotoxins (bothropstoxin, bothropasin and crotoxin) was neutralised by simultaneous exposure of isolated skeletal muscles to an aqueous extract of Eclipta prostrata or to wedelolactone, stigmaterol and sitosterol.
These compounds may have played a role in the inhibitory effect observed, probably owing to the chelation of the zinc required for the catalytic activity of venom's haemorrhagic metalloproteinases [ 45 ] . Reduction in the intensity of the effects of envenomation could also be achieved by a neutralisation of the venom peptides, polypeptides, proteins and enzymes [ 38 11 ] . There are plants used for snakebite that act by inhibiting the proteolytic activities of the venom and antagonising crotoxin-induced haemolysis, myotoxic and haemorrhagic activities of crotalid venoms [ 46 ] .
Crotalus viridis viridis (western rattlesnake) and Agkistrodon contortrix laticinctus (copperhead) and two phospholipase A 2 myotoxins, CVV myotoxin and ACL myotoxin, isolated from them [ 46 ] . Empirical use of Eclipta prostrata alcoholic extracts to treat crotalid envenomation are supported by these studies [ 12 ] .
While proteases, phospholipase A 2 and nucleotidases are responsible for the haemorrhagic lesions induced by Bothrops jararaca venom, most crotalid myotoxins are phospholipases and some exhibit proteolytic activities [ 12 ] . Crotalid snakes have a wide geographical distribution, this may contribute to differences in their venom composition [ 8 ] . Differences in venom composition may play a role in the effectiveness of the medicinal plants used for snakebites.
Eclipta prostrata and its constituents (wedelolactone, stigmaterol and sitosterol) showed good potential against crotalid venoms.
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