Words similar to cross-resistance

Example sentences for: cross-resistance

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Resistance to acyclovir (ACV) or penciclovir (PCV) generally arises by a single base mutation in either the HSV thymidine kinase (TK) or DNA polymerase (Pol) gene [for a review, see reference [ 5 ] ]. Unlike Pol, TK is not essential for virus replication in cell culture [ 7 ] , although in vivo analyses implicate it in HSV virulence, pathogenicity and reactivation from latency [ 4 8 16 22 ] . Since ACV and PCV are dependent upon HSV TK for monophosphorylation, an event obligatory for the formation of the active triphosphate inhibitor [ 14 ] , ACV risolates often exhibit high levels of cross-resistance to PCV [ 2 3 ] .
For example, there has been overreliance on quinolines (such as chloroquine) and antifolates (such as pyrimethamine) resulting in cross-resistance among these drug classes.
, Burkholderia cepacia , and some strains of Stenotrophomonas maltophilia are usually resistant to colistin [ 8 9 10 11 12 13 14 15 16 17 18 ] . Cross-resistance with other antibiotics has not been reported [ 10 13 ] , and acquired resistance is rare [ 11 17 ] . Although lower susceptibility rates for P. aeruginosa have been reported in patients with cystic fibrosis undergoing chronic prophylactic treatment with inhaled colistin [ 18 ] , 81% of strains of P. aeruginosa from such patients are still susceptible to colistin [ 14 ] .