Words similar to crohn
Example sentences for: crohn
How can you use “crohn” in a sentence? Here are some example sentences to help you improve your vocabulary:
In the setting of IBD, the expression of ECAMs like ICAM-1, VCAM-1, and MAdCAM-1 (mucosal addressin cell adhesion molecule-1) is observed in experimental models of colitis, [ 2 3 4 5 ] and also within the inflamed human colon in Crohn's disease and ulcerative colitis [ 6 7 ] .
Although both studies were endoscopically normal, histopathology of random mucosal biopsies revealed characteristic features of Crohn's disease with granulomas in the colon and erosive duodenitis with a single granuloma in the small bowel (Figure 1).
The data suggested clinical benefit as assessed from the mean change from baseline in the Crohn's Disease Severity Index after 21 days at doses of 16 and 40 μg/kg per week ( P < 0.05).
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that may play a role in several disease states, including arthritis, sepsis, Crohn's disease, allograft rejection, asthma and prostate cancer [ 1 2 3 ] . Although MIF was initially described as released from activated T-cells [ 4 5 ] , subsequent investigations have localized MIF in a variety of other cells and tissues (for a recent review [ 1 ] ). For example, pre-formed MIF stores can be found in the epithelia of several organs and may be released in response to endotoxemia [ 6 ] . The role of MIF in the central nervous system remains to be determined, yet neurons in the brain synthesize and rapidly release MIF while glial cells appear to store MIF [ 7 8 ] , and the anterior pituitary gland contains MIF that may be released during endotoxemia [ 9 ] .
While our studies were in progress, other groups detected mutations in the CARD15 gene for a subset of Crohn's disease patients, and in three small Blau syndrome families [ 11 12 ] . The lack of accurate maps is reflected in the position assigned to CARD15 in consecutive genome builds in that CARD15 should map to the 16q13 interval for Blau and Crohn's, yet in build 27 it was mapped close to the p-telomere of chromosome 16.
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