Words similar to crohn
Example sentences for: crohn
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TNFα and TNFβ have been extensively studied and are involved in immune and pro-inflammatory responses, playing an important role in host defenses against infection and other disease states [ 4 5 6 7 ] . The biological effects of TNFα and TNFβ are mediated through the two membrane associated receptors, TNFR1 (p55) and TNFR2 (p75), that are expressed on the target cells [ 8 9 ] . The postulated pathogenic roles for TNF include sepsis and other bacterial and viral pathologies [ 10 11 12 ] , certain cancers [ 13 ] , metastasis [ 14 ] and chronic autoimmune disorders such as rheumatoid arthritis [ 15 16 ] , multiple sclerosis [ 17 ] and Crohn's disease [ 18 ] . It is worth noting that TNFα mutants have been identified that selectively bind TNFR1.
But it is increasingly believed that the loss of worms from our internal ecology is responsible for the upsurge in inflammatory bowel disorders such as Crohn's disease and colitis.
IL-10, a cytokine produced by activated macrophages and Th2-type T cells, has crucial inhibitory effect against several Th-1 type immune responses, such as the antigen-presenting functions of monocytes and macrophages [ 52 53 ] . IL-10 may play an important role in preventing the induction of IBD, since animals deficient in IL-10 will develop colitis spontaneously, and low levels of IL-10 are positively correlated with recurrences of Crohn's disease [ 25 54 ] . However, unlike TNF-α based therapies, the administration of recombinant IL-10 (rIL-10) shows poor clinical efficacy.
Although both studies were endoscopically normal, histopathology of random mucosal biopsies revealed characteristic features of Crohn's disease with granulomas in the colon and erosive duodenitis with a single granuloma in the small bowel (Figure 1).
The phenotype of the Blau syndrome resembles another multisystem granulomatous disorder, Crohn's disease (MIM 266600), and another autoimmune disease, psoriasis (MIM 177900).
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