Words similar to cpg
Example sentences for: cpg
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MeCP2's functional structure consists of an 84 amino acid methyl-binding domain (MBD) [ 11 ] and a 104 amino acid transcriptional repression domain (TRD) [ 12 ] . The MBD is able to bind to 5-methyl cytosine residues of a single CpG dinucleotide [ 11 ] . Under the current model, MeCP2 binds to DNA, then complexes with Sin3A through the TRD and recruits histone deacetylases (HDAC).
Short spikes of CpG islands (for example, in 3p26 and 3p25 of Figure 1) do not obviously appear in the assay, perhaps because they are below the resolution of FISH or are part of transcriptionally active regions.
A nonrandom pattern of promoter hypermethylation has been noted in specific genes in specific tumor types, although some genes are commonly methylated in diverse tumors [ 3 4 ] . The extent of aberrant promoter hypermethylation and its association with loss of gene function in cancer suggests that CpG island methylation is an important mechanism in inactivating tumor suppressor genes (TSGs).
Other epigenetic mechanisms involving defects in chromatin modification factors such as the association of methyl-CpG binding proteins, acetylation and methylation of histone proteins are also becoming known [ 15 ] . The role of these chromatin-mediated components in inactivating the MGMT gene remains to be examined in GCT.
The resulting corrected ideograms and six major genomic features are plotted across the genome in Figure 1. Unique exons (as determined above), CpG islands, genomic GC content, Alu and LINE1 elements, and minisatellites are plotted as densities (proportion of bases belonging to feature) in 1 Mb intervals.
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