Words similar to cox-
Example sentences for: cox-
How can you use “cox-” in a sentence? Here are some example sentences to help you improve your vocabulary:
If uniformly diminished PG synthesis by IDO was responsible for growth of RAW cell macroscopic foci, inhibiting PG synthesis with a pharmacological inhibitor of COX-1 and -2 ought to reproduce the effect of IDO expression.
The available research regarding cognitive function and phytoestrogens suggests that large amounts of phytoestrogens, consumed as tofu, have an adverse influence on cognitive ability in men, where decreased brain weight, increased ventricular size and dementia have been reported [ 44 ] . In ovariectomized female rats, on the other hand, phytoestrogen treatments resulted in a dose-dependent improvement of VSM [ 45 ] . This improvement in cognitive ability in phytoestrogen treated females may be due in part to the increased presence of choline acetyltransferase messenger RNA in the frontal cortex, which has been shown to be associated with protection and enhancement of cognitive function [ 45 ] . Furthermore, we have shown that phytoestrogens significantly affect the brain calcium-binding protein calbindin (CALB), which acts as a buffer by binding intracellular calcium and plays an important role in mediating cell proliferation, programmed cell death (apoptosis), and neurotoxicity [ 48 49 50 51 52 ] . This neuroprotective mechanism via CALB appears to be important in neurological disorders such as Parkinson's disease and Huntington's disease [ 48 49 50 51 52 ] . Additionally, Cyclooxygenase-2 (COX-2) seems to play an important role in mediating functional neuronal maturation and responses to certain stimuli in the brain [ 53 54 55 ] . The expression of COX-2 is associated with key pathophysiologic events in Alzheimer's disease: deposition of beta-amyloid protein in neuritic plaques within the hippocampus and cortex [ 53 54 55 ] . Of particular importance to this study is the fact that COX-2 has been shown to be influenced by steroidal hormones [ 53 54 55 ] . Therefore, the expression of COX-2 in the frontal cortex may also be hormonally regulated and relevant to cognitive decline.
The primers (5' or 3') used for COX-2 were sense primer, CAT TCT TTG CCC AGC ACT TCA C and antisense primer, GAC CAG GCA CCA AGA CCA AAG AC.
After transfer, the filters were incubated overnight at 4°C in a blocking solution (20 mM TRIS base, 137 mM sodium chloride at pH 7.6, 5% powdered milk, 3% BSA), and incubated with primary polyclonal rabbit antibodies against COX-2 at a dilution 1:1000 (Cayman Chemical, Ann Arbor, MI), for 1 hour at room temperature.
Because the expression of COX-2 is associated with key pathophysiologic event(s) in Alzheimer's disease [ 53 54 55 ] , the significant increase in COX-2 expression in the frontal cortex may be relevant to the cognitive decline seen in the Phyto-600 males.
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