Words similar to cox-
Example sentences for: cox-
How can you use “cox-” in a sentence? Here are some example sentences to help you improve your vocabulary:
The available research regarding cognitive function and phytoestrogens suggests that large amounts of phytoestrogens, consumed as tofu, have an adverse influence on cognitive ability in men, where decreased brain weight, increased ventricular size and dementia have been reported [ 44 ] . In ovariectomized female rats, on the other hand, phytoestrogen treatments resulted in a dose-dependent improvement of VSM [ 45 ] . This improvement in cognitive ability in phytoestrogen treated females may be due in part to the increased presence of choline acetyltransferase messenger RNA in the frontal cortex, which has been shown to be associated with protection and enhancement of cognitive function [ 45 ] . Furthermore, we have shown that phytoestrogens significantly affect the brain calcium-binding protein calbindin (CALB), which acts as a buffer by binding intracellular calcium and plays an important role in mediating cell proliferation, programmed cell death (apoptosis), and neurotoxicity [ 48 49 50 51 52 ] . This neuroprotective mechanism via CALB appears to be important in neurological disorders such as Parkinson's disease and Huntington's disease [ 48 49 50 51 52 ] . Additionally, Cyclooxygenase-2 (COX-2) seems to play an important role in mediating functional neuronal maturation and responses to certain stimuli in the brain [ 53 54 55 ] . The expression of COX-2 is associated with key pathophysiologic events in Alzheimer's disease: deposition of beta-amyloid protein in neuritic plaques within the hippocampus and cortex [ 53 54 55 ] . Of particular importance to this study is the fact that COX-2 has been shown to be influenced by steroidal hormones [ 53 54 55 ] . Therefore, the expression of COX-2 in the frontal cortex may also be hormonally regulated and relevant to cognitive decline.
One of the proposed mechanisms for the chemopreventive properties of aspirin and other NSAIDs points to the observation that NSAIDs inhibit prostaglandin (PG)-endoperoxide synthase (cyclooxygenase) enzymes [ 24 ] , of which two forms of similar enzymatic activity exist, COX-1 and COX-2.
The 18S primer: competimer (Ambion Inc., Austin, TX, USA) ratio was adjusted to produce an amplification signal in the linear range of the COX-2 and TNF-α products, to normalize each COX-2 and TNF-α.
In male and female rats from experiments 1 and 2, CALB and COX-2 levels in the frontal cortex and hippocampus (CALB only) were determined using Western blot analysis, as reported elsewhere [ 49 55 ] . In brief, homogenized samples (30 μg per lane for frontal cortex and hippocampus- by treatment) were resolved on 14% Tri-Glycine gels and transferred onto Millipore Immobilon-P membranes (Millipore, Bedford, MA, USA) by electroblotting.
Baseline and stimulated COX-2 expression
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