Words similar to cox-
Example sentences for: cox-
How can you use “cox-” in a sentence? Here are some example sentences to help you improve your vocabulary:
MC57 cells, which demonstrated similar changes in cell adhesion to RAW cells following IDO expression, exhibited lower levels of COX-2 synthesis upon IDO expression and lower levels of PG E 2 relative to other PGs such as D 2 . Furthermore, adding back PGE 2 to IDO-expressing MC57 cells did not reproduce the wild type phenotype (not shown).
After transfer, the filters were incubated overnight at 4°C in a blocking solution (20 mM TRIS base, 137 mM sodium chloride at pH 7.6, 5% powdered milk, 3% BSA), and incubated with primary polyclonal rabbit antibodies against COX-2 at a dilution 1:1000 (Cayman Chemical, Ann Arbor, MI), for 1 hour at room temperature.
Of significance is the fact that the COX-2 gene is known to be NF-κB dependent, and IL-1β, but not TGFβ, is a potent inducer of NF-κB activation.
Induction of COX-2 mRNA following endotoxin administration was correlated with expression of COX-2 protein.
It has also been shown that aspirin inhibited nitrosamine induced lung carcinogenesis [ 27 ] , and it reduced COX-2 enzyme levels in lung cancer cell lines [ 28 ] . Further support for a potential role of the COX-2 pathway in lung cancer development comes from several investigations that demonstrated COX-2 overexpression in human lung tumors, specifically NSCLC [ 29 30 31 32 ] and precursor lesions [ 33 ] . While COX-2 expression was generally shown to be increased in NSCLC and to a much lesser extent in SCLC, the role of COX-2 expression in latter tumor type is difficult to determine, due to the fact that the numbers of SCLC tumors examined in these studies was very small.
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