Words similar to covariation-based
Example sentences for: covariation-based
How can you use “covariation-based” in a sentence? Here are some example sentences to help you improve your vocabulary:
Base pair frequencies are presented for a) all base pairs in the current covariation-based structure models, b) tentative base pairs predicted with covariation analysis, and c) base pairs previously proposed with comparative analysis that are not included in our current structure models due to a lack of comparative support from the analysis with our best covariation methods on our current alignments (named "Lousy" base pairs).
Recently, we utilized this system to identify and quantitate the following biases for adenosines in the Bacterial 16S and 23S rRNA covariation-based structure models [ 63 ] : 1) approximately 2/3 of the adenosines are unpaired; 2) more than 50% of the 3' ends of loops in the 16S and 23S rRNA have an A; 3) there is a bias for adenosines to be adjacent to other adenosines (66% of these are at two unpaired positions, and 15% of these are at paired/unpaired junctions); and 4) the majority of the As at the 3' end of loops are adjacent to a paired G. These results were discerned with this system and are shown in part in Figure 5and H-4C.
The third, named "bpseq," is a simple text format that contains the sequence, one nucleotide per line, its position number, and the position number of the pairing partner (or 0 if that nucleotide is unpaired in the covariation-based structure model).
The 16S and 23S rRNA covariation-based structure models have undergone numerous revisions [ 23 24 25 26 27 28 ] . Today, with a significantly larger number of sequences and more advanced covariation algorithms, we search for all positional covariations, regardless of the types of pairings and the proximity of those pairings with other paired and unpaired nucleotides.
Our objective is to categorize the improvements in these covariation-based comparative structure models by tabulating the presence or absence of every proposed base pair in each version of the 16S and 23S rRNA structure models, starting with our first 16S [ 15 ] and 23S [ 19 ] rRNA models.
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