Words similar to copii

Example sentences for: copii

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The screen for NPC assembly/mislocalization mutants identified two genes that are part of the COPII coat, SEC13 and SEC23 . To test if other members of the COPII coat complex were isolated in the screen, conditional alleles in SEC16 , SEC24 , SEC31 , SAR1 , and SEC12 were kindly provided by other investigators, and tested directly for their effect on NPC localization.
However, not all of the COPII components co-fractionate with NPCs [ 5 6 42 ] . Thus, there are COPII components that perturb GFP-Nup localization that do not co-fractionate with NPCs.
Testing other COPII coat and secretory pathway components for npagroups
Bet3p is part of a complex that binds to COPII derived vesicles and is required for vesicle targeting [ 47 48 ] . Sec27p is a component of the COPI coat and required for Golgi to ER transport [ 49 50 ] . Like SEC23 and SEC13 mutants, others have reported that mutants in BET3 and SEC27 result in an over-proliferation of ER membranes [ 49 51 ] .
The phenotypes observed in sec13 and sec23 mutants might indicate that COPII vesicles and/or a vesicular biogenesis step is required for NPC formation; however, there are at least two indirect mechanisms by which NPC structure may be changed in these mutants.