Words similar to coordinately
Example sentences for: coordinately
How can you use “coordinately” in a sentence? Here are some example sentences to help you improve your vocabulary:
Members of this family include RhoA, RhoB, RhoC (which are isoforms), Cdc42, G25K, RhoG, Rac1, Rac2, and TC10 (reviewed in [ 34 ] ). In fibroblast models, these GTPases have been proposed to act in a concerted hierarchy to coordinately regulate distinct morphological features.
To simplify this task, genes whose products function together are often under common regulatory control such that they are coordinately expressed under the appropriate conditions.
Of these genes, all but 6 were included among the 93 genes coordinately expressed in the in vitro and in vivo time courses (Figure 3).
It is known that during clonal selection in the thymus, immature CD4, CD8 double positive cells develop into single positive CD4 or CD8 cells according to the relative affinity of their TCR to class II or class I molecules respectively [ 5 6 ] . These immature T-cells are selected in the thymic epithelium on the basis of their TCR interaction with either class I or class II MHC molecules [ 7 8 ] , thus generating two mutually exclusive subpopulations that are characterized by the expression of either CD4 or CD8 glycoproteins [ 9 ] . Earlier studies in the murine system have demonstrated that PMA and cAMP can modulate the expression CD4 and CD8 on developing thymocytes [ 10 11 12 13 ] . In keeping with these findings, ex vivo experiments with human thymocytes previously reported by our group, revealed that while phorbol esters can coordinately regulate the transcription of α and β TCR during intrathymic T cell differentiation [ 14 ] , cAMP selectively affected the transcription of the α and δ-TCR [ 15 16 ] . Together the murine data and our own findings support the hypothesis that in humans, TCR expression and CD4, CD8 commitment and selection may be regulated by the same signal-transduction pathways.
While this assumption may be a reasonable first approximation, it does not allow for the possibility of a cross-product relationship in which a group-specific variable (for example, toxic exposure) might lead to informative sub-states that exhibit separate groups of coordinately regulated responsive genes as a function of the extent to which the individual responds.
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