Words similar to convertase

Example sentences for: convertase

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LIF and LIFR are functionally expressed in rodent tissues that are central to GC production: the hypothalamus [ 8 ] and pituitary [ 9 10 11 12 ] . LIF works in synergy with corticotropin-releasing hormone (CRH) in the hypothalamus to increase pituitary pro-opiomelanocortin (POMC) and, ultimately, pituitary adrenocorticotrophin hormone (ACTH) [ 9 11 13 14 15 16 ] . LIF also stimulates POMC gene expression directly in the pituitary [ 9 11 15 17 ] . LIF up-regulates pituitary prohormone convertase (PC1).
This is an ADAM10-homolog known to be a tumor necrosis factor-α (TNFα) convertase [ 21 ] , TNFα produced by Kupffer cells in the liver stimulates production of TNFα, a mitogen for hepatocytes helping to generate new cells needed to rebuild damaged areas of the liver [ 22 ] . Kupffer cells have a significant role as mediators of acute inflammation after CCl 4 treatment; however, they also produce factors that can cause secondary injury in the liver through fibrogenic responses.
In this respect, a shift to constitutive secretion has been reported to occur by the experimental induction of dysfunctional prohormone convertase enzymes or by injury to the plasma membrane [ 29].
An increase in a TNFα convertase would ensure that any residual cytokine present would be in the active stimulatory form.