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Example sentences for: contraindications
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[ 21 ] Therefore, use of antiretroviral therapy would be expected in patients with HIVAN in the absence of definite contraindications, even disregarding the previously cited reports of a possible beneficial effect of HAART on the course of HIVAN itself.
This list includes all the questions on the questionnaire except those addressing: reasoning underlying one's attitude toward vaccination, contraindications, and projected behavior under hypothetical scenarios.
The questionnaire (see Additional File 2) consisted of 17 multiple-choice questions, mostly about respondents' attitudes and projected behavior regarding smallpox and smallpox vaccination, knowledge and topics of concern, and self-assessed health history relative to smallpox vaccination (previous vaccination, contraindications).
Even if these findings are not confirmed after further study, one could still make a compelling argument that lipid-lowering therapy (barring contraindications) should be initiated early and universally in patients who present with an acute coronary syndrome: First, the long-term safety and effectiveness of statins for the secondary prevention of stable coronary disease is well-established [ 1 2 3 ] ; Second, as evidenced by MIRACL, these agents are safe when initiated at the time of hospitalization for an acute coronary syndrome; Third, the in-hospital initiation of lipid-lowering therapy appears to promote greater long-term utilization of these agents [ 18 19 20 21 ] . Finally, although lipid levels may be unreliable in the setting of an acute coronary syndrome (excepting total :HDL and LDL:HDL cholesterol ratios [ 22 ] ) the overwhelming majority of patients with coronary disease will ultimately require both pharmacologic and non-pharmacologic lipid-lowering interventions to attain recommended cholesterol targets [ 23 24 25 ] ; newer guidelines are even more stringent [ 26 ] . Furthermore, data from the recently presented Heart Protection Study suggest that clinical benefits may accrue independent of baseline cholesterol level [ 4 ] . Thus, to withhold lipid-lowering therapy from patients who present with an acute coronary syndrome would be to accept the status quo, and to date our efforts at cholesterol lowering in the secondary prevention setting have been dismal [ 27 28 ] .
Forty-five percent of those who completed the question on contraindications said either "yes" (37%) or "don't know" (8%) to at least one of the contraindications in our list of 8. The most common (self-reported) contraindication was household member with current or past history of eczema or atopic dermatitis - 16% of respondents reported this situation.
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