Words similar to contractility
Example sentences for: contractility
How can you use “contractility” in a sentence? Here are some example sentences to help you improve your vocabulary:
Prior to the infusion of saline, group differences were already apparent between iron deficient and control rats at 1 month in heart rate (*, p = 0.0025), systolic (*, p = 0.0041) and diastolic pressure (*, p = 0.0020), but not contractility (p = 0.6373).
is expressed in skeletal muscle, with a less abundant ~7 kb transcript expressed in both skeletal and cardiac muscle [ 8 ] . Whereas tropomodulins or the Arp 2/3 complex cap the pointed end of actin filaments, the barbed end can be capped by CapZ, α, β, and γ adducins as well as gelsolin [ 9 10 11 ] . Control of thin filament length is critical for maintaining proper sarcomere function and length [ 12 ] . Inhibition of Tmod1's capping activity - either by using an antibody to its C-terminal end or by decreasing expression using an antisense Tmod1 transcript - results in elongated thin filaments and decreased cardiac contractility [ 13 14 ] . Tmod1 overexpression in rat cardiomyocytes causes shortening of the thin filaments and sarcomere disorganization, resulting in myofibril degeneration [ 14 ] . Likewise, mice overexpressing TMOD1 in the heart show disrupted sarcomere organization with shortened thin filaments, leading to myofibril degeneration and dilated cardiomyopathy [ 15 ] . Recently, Littlefield and colleagues showed that overexpression of GFP-Tmod1 in chick cardiac myocytes results in shortening of thin filaments; the authors proposed that excess Tmod1 decreases the affinity between actin monomers and pointed ends, leading to monomer dissociation and filament shortening [ 42 ] . Mutations in many proteins making up the cardiac sarcomere have been shown to cause cardiac hypertrophy [ 16 17 18 19 ] :mutations in the TPM1 gene, for example, cause type 3 familial hypertrophic cardiomyopathy (CMH3), and a transgenic mouse expressing a CMH3 mutation develops ventricular myocyte disarray and hypertrophy [ 20 ] . Mutations in myosin heavy chain 7 are estimated to account for 40-50% of the cases of hypertrophic cardiomyopathy [ 21 ] .
Prior to norepinephrine infusion, there were no differences between iron deficient and control groups within each duration in either heart rate or contractility (p > 0.05).
Figure 3also shows heart rate and contractility immediately prior to, and at peak response to, intravenous norepinephrine infusions.
Iron deficient cardiac hypertrophy is not unique in this regard, as Lin has recently documented enhanced contractility without increased heart rate in hyper-sympathetic transgenic mice [ 34 ] . In contrast, there is a large body of evidence which suggests that cardiac hypertrophy which has progressed to the point of pathology, ultimately results in a decrease in contractility [ 25 26 27 29 30 32 33 44 45 ] . We have not yet investigated whether the iron deficient heart will similarly lose the augmented contractility response in time.
Loading...