Words similar to contractility
Example sentences for: contractility
How can you use “contractility” in a sentence? Here are some example sentences to help you improve your vocabulary:
It is therefore not a specific parameter, since its variation is due to the changes of one or more of the related factors (preload, afterload or contractility) [ 20, 21].
First, we hypothesized that in iron deficient rats, intravenous norepinephrine would cause an altered cardiovascular response, either in heart rate or rate of arterial pressure generation (contractility, dp•dt -1).
For example, Engelhardt [ 46 ] , in a study of mice genetically bred with an increase in beta-adrenergic receptor density, showed that increased contractility was an initial response, but by 35 weeks contractility was reduced by 50% and ejection fraction by 20%.
Iron deficient cardiac hypertrophy is not unique in this regard, as Lin has recently documented enhanced contractility without increased heart rate in hyper-sympathetic transgenic mice [ 34 ] . In contrast, there is a large body of evidence which suggests that cardiac hypertrophy which has progressed to the point of pathology, ultimately results in a decrease in contractility [ 25 26 27 29 30 32 33 44 45 ] . We have not yet investigated whether the iron deficient heart will similarly lose the augmented contractility response in time.
is expressed in skeletal muscle, with a less abundant ~7 kb transcript expressed in both skeletal and cardiac muscle [ 8 ] . Whereas tropomodulins or the Arp 2/3 complex cap the pointed end of actin filaments, the barbed end can be capped by CapZ, α, β, and γ adducins as well as gelsolin [ 9 10 11 ] . Control of thin filament length is critical for maintaining proper sarcomere function and length [ 12 ] . Inhibition of Tmod1's capping activity - either by using an antibody to its C-terminal end or by decreasing expression using an antisense Tmod1 transcript - results in elongated thin filaments and decreased cardiac contractility [ 13 14 ] . Tmod1 overexpression in rat cardiomyocytes causes shortening of the thin filaments and sarcomere disorganization, resulting in myofibril degeneration [ 14 ] . Likewise, mice overexpressing TMOD1 in the heart show disrupted sarcomere organization with shortened thin filaments, leading to myofibril degeneration and dilated cardiomyopathy [ 15 ] . Recently, Littlefield and colleagues showed that overexpression of GFP-Tmod1 in chick cardiac myocytes results in shortening of thin filaments; the authors proposed that excess Tmod1 decreases the affinity between actin monomers and pointed ends, leading to monomer dissociation and filament shortening [ 42 ] . Mutations in many proteins making up the cardiac sarcomere have been shown to cause cardiac hypertrophy [ 16 17 18 19 ] :mutations in the TPM1 gene, for example, cause type 3 familial hypertrophic cardiomyopathy (CMH3), and a transgenic mouse expressing a CMH3 mutation develops ventricular myocyte disarray and hypertrophy [ 20 ] . Mutations in myosin heavy chain 7 are estimated to account for 40-50% of the cases of hypertrophic cardiomyopathy [ 21 ] .
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