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Example sentences for: conserved
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The fourth ligand appears to be a water molecule activated through interactions with the conserved glutamate to serve as the active site nucleophile.
Calnexin, Calreticulin, GRP94 (glycoprotein 96) and GRP78 (BiP) have been identified on the cell surface of immature thymocytes [ 16 17 ] . Cell surface expression of GRP94 is found in lymphocytes and lymphoid-like cells from several vertebrate species and is phylogenetically conserved [ 18 ] . Calnexin has been found on the surface of pro-B cells [ 19 ] , as well as in a variety of mammalian culture cells [ 20 ] and a number of HSPs are found expressed on the cell surface in human and murine tumor cells [ 21 22 23 24 ] . Calreticulin, GRP78 and PDI were described on the plasma membrane of different cell types [ 25 26 27 28 ] ; GRP78, GRP94, and PDI, have been found on the surface of rat exocrine pancreatic cells [ 29 30 ] , and GRP78 cell surface expression was recently shown in human endothelial cells [ 31 ] .
Comparison of the sequences of the CD5 promoters cloned from man and mouse [ 25, 26] revealed conserved transcription factor binding sites.
These conserved sub-structures, which often have readily identifiable boundaries, may recur in a large number of different proteins in which they perform a similar function.
The connection between nucleic acid methylation and the AlkB homologs described here is supported by the domain architecture of a conserved pair of animal proteins (C14B1.
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