Example sentences for: congenic

How can you use “congenic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Doherty and Zinkernagel [ 20 ] demonstrated using congenic mice that MHC homozygotes had more vigorous immune responses to lymphocytic choriomeningitis virus (LCMV) than the corresponding homozygotes, but since the pathology of the infection they used is due to the immune response, the enhanced immune response actually resulted in reduced survival.

  • Finally, it should be pointed out that even when a synonymous sequence difference is found between QTL strains, it can still be used as a new, easily scored marker to further narrow the QTL interval using fine-mapping resources such as interval-specific congenic recombinant mice [ 33].

  • A number of interval-specific congenic strains have recently been developed for a number of QTLs and, although straightforward, fine mapping is still a large-scale enterprise because of the need to generate and test large numbers of animals to identify and behaviorally assess informative recombinants, and because of the need for markers to detect such recombination events.

  • All mice were maintained as congenic on a C57BL/6 genetic background.

  • The immediate consequence of this work should be an increased scrutiny for appropriate controls, which may include congenic mice carrying the same 129 flanking region, but expressing the targeted gene (Figure 2).


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