Example sentences for: congenic

How can you use “congenic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • A number of interval-specific congenic strains have recently been developed for a number of QTLs and, although straightforward, fine mapping is still a large-scale enterprise because of the need to generate and test large numbers of animals to identify and behaviorally assess informative recombinants, and because of the need for markers to detect such recombination events.

  • Doherty and Zinkernagel [ 20 ] demonstrated using congenic mice that MHC homozygotes had more vigorous immune responses to lymphocytic choriomeningitis virus (LCMV) than the corresponding homozygotes, but since the pathology of the infection they used is due to the immune response, the enhanced immune response actually resulted in reduced survival.

  • A related ongoing development that should help this situation by reducing the number of potential candidate genes that remain within the QTL interval is reduction of the interval by fine mapping using specialized congenic strains or recombinant progeny testing [ 33, 38].

  • All mice were maintained as congenic on a C57BL/6 genetic background.

  • In this context, it is important to note that 3 other mutant loci have been reported in the SHR rat; missense mutations in the KAT-1 (kynurenine aminotransferase-1), Srebf-1 (sterol regulatory element binding factor-1) and CD36 (fatty acid translocase) are all present as homozygous changes [ 46 47 48 ] . The generation of congenic lines may assist with addressing many of these issues.


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