Words similar to congenic
Example sentences for: congenic
How can you use “congenic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Doherty and Zinkernagel [ 20 ] demonstrated using congenic mice that MHC homozygotes had more vigorous immune responses to lymphocytic choriomeningitis virus (LCMV) than the corresponding homozygotes, but since the pathology of the infection they used is due to the immune response, the enhanced immune response actually resulted in reduced survival.
In this context, it is important to note that 3 other mutant loci have been reported in the SHR rat; missense mutations in the KAT-1 (kynurenine aminotransferase-1), Srebf-1 (sterol regulatory element binding factor-1) and CD36 (fatty acid translocase) are all present as homozygous changes [ 46 47 48 ] . The generation of congenic lines may assist with addressing many of these issues.
The immediate consequence of this work should be an increased scrutiny for appropriate controls, which may include congenic mice carrying the same 129 flanking region, but expressing the targeted gene (Figure 2).
A related ongoing development that should help this situation by reducing the number of potential candidate genes that remain within the QTL interval is reduction of the interval by fine mapping using specialized congenic strains or recombinant progeny testing [ 33, 38].
All mice were maintained as congenic on a C57BL/6 genetic background.
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