Words similar to congenic
Example sentences for: congenic
How can you use “congenic” in a sentence? Here are some example sentences to help you improve your vocabulary:
The immediate consequence of this work should be an increased scrutiny for appropriate controls, which may include congenic mice carrying the same 129 flanking region, but expressing the targeted gene (Figure 2).
Finally, it should be pointed out that even when a synonymous sequence difference is found between QTL strains, it can still be used as a new, easily scored marker to further narrow the QTL interval using fine-mapping resources such as interval-specific congenic recombinant mice [ 33].
A number of interval-specific congenic strains have recently been developed for a number of QTLs and, although straightforward, fine mapping is still a large-scale enterprise because of the need to generate and test large numbers of animals to identify and behaviorally assess informative recombinants, and because of the need for markers to detect such recombination events.
In this context, it is important to note that 3 other mutant loci have been reported in the SHR rat; missense mutations in the KAT-1 (kynurenine aminotransferase-1), Srebf-1 (sterol regulatory element binding factor-1) and CD36 (fatty acid translocase) are all present as homozygous changes [ 46 47 48 ] . The generation of congenic lines may assist with addressing many of these issues.
Doherty and Zinkernagel [ 20 ] demonstrated using congenic mice that MHC homozygotes had more vigorous immune responses to lymphocytic choriomeningitis virus (LCMV) than the corresponding homozygotes, but since the pathology of the infection they used is due to the immune response, the enhanced immune response actually resulted in reduced survival.
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