Example sentences for: conferred

How can you use “conferred” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The T790M mutation could also affect the kinase activity or alter the substrate specificity of mutant EGFRs, such that a proliferative advantage would be conferred upon cells bearing the mutation.

  • As shown in Figure 7A, asbt conferred active bile acid uptake activity in transfected cells.

  • For example, early investigators observed that transfection of untransformed B cells with a plasmid for constitutive expression of IL-6 conferred the tumorigenic phenotype on the cells [ 2 ] . IL-6 is a key factor in myeloma progression and survival [ 3 4 ] , and also in Kaposi's sarcoma, a solid tumor [ 5 ] . In myeloma, the standard therapy for treatment includes prednisone, which acts by inhibiting IL-6 synthesis.

  • To gain further insight into the specificity of bile acid cytotoxicity, we conferred active bile acid uptake capacity in CHO cells, a cell type that does not normally metabolize bile acids, by expressing a bile acid transporter.

  • In contrast, our data showed that the 185delAG mutation, affecting the amino-terminal domain of BRCA1, conferred an increased apoptotic response with no caspase pathway preferentially selected.


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