Words similar to conduction
Example sentences for: conduction
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The development of well-characterized cardiac progenitor cells offers the promise of using real genetic-based approaches to rapidly define the complex pathways that guide cardiac contractility, excitability, and lineage diversification into atrial, ventricular, and conduction system myocyte cell lineages.
These differentiation criteria have been used by others in studies of non-limb muscles where conduction velocity of only the very fastest spindle fibers can be associated with primary spindle endings [ 12 13 ] . The data recorded on magnetic tape was analyzed with the aid of the Spike 2 (Cambridge Electronics Design, Ltd.) computer program.
2 locus [ 9 ] . Mutations in the LMNA gene associated with DCM have a more severe prognosis and higher-event rates compared to individuals with DCM that do not have LMNA mutations [ 20 ] . A recent report describing another family with a LMNA mutation causing DCM and conduction system disease documents the need for permanent pacemaker implantation [ 21 ] . Previous reports on the proband's kindred support a high-event rate in family members often resulting in sudden cardiac death even in family members with permanent pacemakers [ 10 ] . For example, ten out of 38 family members with pacemakers for high-grade atrioventricular block died suddenly.
In 24 children with inherited disorders of fatty acid oxidation, conduction defects or arrhythmias were the predominant presenting feature [ 14 ] . Arrhythmias in association with hepatomuscular symptoms and hyperammonemia have also been demonstrated in cases of carnitine-acylcarnitine translocase deficiency whose presenting features also include neonatal distress, convulsions, hypoglycemia, hypoketonemia, intermittent dicarboxylic aciduria, hypothermia, apnea, neurological deterioration, and hypocarnitinemia with grossly elevated acylcarnitines [ 15 ] . The accumulation of arrhythmogenic metabolites of fatty acids, such as long chain acylcarnitines, may be responsible for the observed lethal cardiac defects.
Cardiac conduction disturbance has also been recognized in the mitochondrial cytopathy, Kearns-Sayre syndrome (Mendelian inheritance in Man database *530000), characterized as progressive external ophthalmoplegia and retinopathy [ 16 ] . Clinical manifestations of cardiac disease occur in 57% of patients with Kearns-Sayre syndrome [ 17 ] . The complete AV block in Kearns-Sayre syndrome may also be associated less commonly with ventricular tachycardia, torsade de pointes and ventricular fibrillation as the ultimate and often fatal stage of the condition [ 18 ] . However, to our knowledge, ventricular tachycardia as a presenting feature has not been described in the context of mitochondrial cytopathies in the neonatal period.
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