Words similar to concomitant
Example sentences for: concomitant
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A role in rRNA maturation is suggested by the observation that antisense oligodeoxynucleotide-mediated reduction in human RNase III levels also causes a decrease in the amount of 5.8 S rRNA and a concomitant increase in the 12 S precursor [ 18 ] . A similar defect in rRNA maturation is seen upon U8 snoRNA depletion in Xenopus oocytes [ 26 ] . As U8 snoRNA participates in rRNA maturation, it is possible that an RNase III-dependent step also involves U8 snoRNA.
In summary, in our experiments the in vitro effect of a 1-6 hour exposure to domoic acid on rat neonatal microglia activation and concomitant TNF-α, MMP-9 and O 2 - release was clearly distinct in its magnitude from that observed after exposure to LPS, an agent involved in endotoxic shock and other central nervous pathologies [ 3 ] . Even though this present study was limited to the study of the in vitro effects of domoic acid on three microglia mediators, namely TNF-α, MMP-9 and O 2 -, it provides the first experimental evidence to our knowledge that domoic acid, at in vitro concentrations that are toxic to neuronal cells, can trigger a limited activation of rat neonatal microglia and the concomitant release of modest though statistically significant amounts of TNF-α and MMP-9.
A very early event marking the initiation of development is a substantial reduction in overall translation initiation and a concomitant major shift of ribosomes from mRNA-associated ribosomes (polysomes) to free ribosomes [ 22 23 ] . The percentage of mRNA associated with polysomes drops from about 80-90% in growing cells to 50-60% within several minutes of the removal of the food source.
Attention was given to the stage of disease at the time of admission, prevalence of symptoms on admission and in the final phase, changes of symptoms during treatment, type and duration of sedation until death, survival time after administration of the sedatives, provision of concomitant therapy, nutrition supply and fluids, state of consciousness and communication skills.
A highly ordered chromatin structure presents a physical obstacle for gene transcription; presumably by limiting the access of transcription factors and RNA polymerase II core machinery to target DNA [ 82 83 ] . In concert with the observation that corepressors are associated with HDAC activities [ 84 85 ] , it appears that the transcriptional outcome of nuclear receptors is determined by the balance of histone acetylation and deacetylation activities, and that ligands serve as a switch to recruit HATs with the concomitant dismissal of HDACs.
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