Example sentences for: comt

How can you use “comt” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The Valine allele was shown to be preferentially transmitted to ADHD probands and was associated with impulsive false alarm errors on a continuous performance task [ 56 ] . Several studies on obsessive compulsive disorder have found associations with COMT [ 57 58 59 60 ] . Associations with bipolar disorder [ 61 ] and temperamental dimensions [ 62 ] have also been reported.

  • A recent finding showed that COMT genotype was related to performance on the Wisconsin Card Sorting Test of executive cognition [ 55 ] . In addition, those subjects with the Methionine alleles needed less prefrontal cortical activity, as judged by fMRI, to show the same level of performance on the N-back task.

  • The catechol-O-methyltransferase (COMT) gene is located on chromosome 22q11 [ 52 ] and catalyzes the degradation of catecholamines in conjuction with monoamine oxidase.

  • As an initial assessment of this approach, we chose four candidate genes (DRD4, DAT1, COMT and MAOA) that are among the most widely studied and repeatedly associated with various psychiatric disorders where attention is found to be disrupted.

  • Previous biochemical studies on MAO and COMT have shown that the COMT Valine isoforms have 4-fold higher levels of enzymatic activity than the Methionine isoform.


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