Words similar to comt
Example sentences for: comt
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For genotyping of the COMT Val to Met change at position 108 as described in [ 91 ] , Forward: 5'-ACTGTGGCTACTCAGCTGTG-3' and Reverse 5'-CCTTTTTCCAGGTCTGACAA-3' primers were used followed by restriction digestion with NlaIII.
The Valine allele was shown to be preferentially transmitted to ADHD probands and was associated with impulsive false alarm errors on a continuous performance task [ 56 ] . Several studies on obsessive compulsive disorder have found associations with COMT [ 57 58 59 60 ] . Associations with bipolar disorder [ 61 ] and temperamental dimensions [ 62 ] have also been reported.
As an initial assessment of this approach, we chose four candidate genes (DRD4, DAT1, COMT and MAOA) that are among the most widely studied and repeatedly associated with various psychiatric disorders where attention is found to be disrupted.
Figure 4shows the distributions for 30 subjects who carry the (Val/Val and 4/4) genotype and 20 subjects who carry the (Met/Met and 3/3) genotypes at COMT and MAOA respectively.
In the prefrontal cortex, the breakdown of synaptic dopamine through the COMT pathway is more critical since PFC is characterized by greater extracellular diffusion & slower clearance of dopamine than elsewhere in the brain [ 53 ] . The most widely examined polymorphisms in COMT were identified by Lachman [ 54 ] who found a G-to-A change at codons 108 and 158 of the COMT gene, resulting in Valine-to-Methionine substitutions which account for 3- to 4-fold differences in COMT activity in red blood cells and liver.
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