Words similar to composition-based

Example sentences for: composition-based

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The non-redundant (NR) database of protein sequences (National Center for Biotechnology Information, NIH, Bethesda) was searched using the BLASTP program [ 100 ] . Position-specific scoring matrix (PSSM) searches were conducted using the PSI-BLAST program, typically with a PSSM inclusion expectation (E) value threshold of 0.01, and were iterated until convergence [ 100 101 ] . Prior to PSI-BLAST searches, query sequences were evaluated for compositional bias using the SEG program [ 102 ] . If no such bias was detected, searches were run with the composition-based statistics turned off, in order to maximize sensitivity [ 103 ] . Multiple alignments of protein sequence were constructed using the T_Coffee program [ 104 ] , followed by manual correction based on the PSI-BLAST results.
In searches carried out with just the globular domain of a particular protein, the composition-based statistics was not used because this helps in improving the sensitivity of searches without a major risk of corruption of the profile with false positives [ 37].
If whole-length proteins were used, the searches were carried out using the composition-based statistics [ 37] in order to prevent the detection of spurious matches that could arise from low-complexity segments in the query or target proteins.