Words similar to complementarity-dependent

Example sentences for: complementarity-dependent

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In contrast to the ubiquitous DDRP, cellular RDRPs that are involved in PTGS so far have been detected only in eukaryotes [ 1 26 ] . The PTGS phenomenon covers a variety of complementarity-dependent silencing pathways, such as RNA interference (RNAi) in animals and slime mold, co-suppression (silencing of transgene and the corresponding endogenous genes) and virus gene resistance in plants, and quelling in fungi, all of which share a common mechanism of RNA turnover [ 28 37 38 39 40 ] . Essentially, double-stranded (ds) RNA, which is formed in these processes, triggers the activation of a sequence-specific RNA degradation system, which targets homologous RNAs [ 41 42 ] . The dsRNA is broken down by the Dicer enzyme into 21-25 nucleotide (nt) fragments called small interfering RNA or siRNAs [ 43 44 45 ] . The siRNAs subsequently associate with a complex of proteins called RISC and target homologous RNA by serving as guides for multiple rounds of RNA cleavage [ 45 46 ] .