Words similar to colocalization
Example sentences for: colocalization
How can you use “colocalization” in a sentence? Here are some example sentences to help you improve your vocabulary:
This putative association is strengthened by finding for the first time that targeting of RIα requires the AKAP binding surface [ 17 ] . Yotiao is another AKAP enriched at the NMJ, but appears to bind only RII [ 30 ] . PKA phosphorylates the nAChR when stimulated at the synapse by the neuropeptide CGRP and by adenosine from muscle responding to acetylcholine [reviewed by [ 31 ] ]. This phosphorylation may regulate the degradation of the nAChR [ 32 ] . Consistent with the action at the presynapse, it was shown that PKA facilitation of acetylcholine release is dependent on nerve endplate calcium concentration [ 33 ] . Based on our observation of colocalization with synaptophysin at presynaptic vesicles, RIα may be the isotype that influences this release of neurotransmitter.
We were able to localize the components of this trimolecular complex to the synovial lining layer in consecutive tissue sections, a finding that is consistent with their colocalization.
It is to be expected that with greater stimulation time the colocalization would increase, which presents the prospect of studying the relative dynamics of AChR and α-DG colocalization.
Accordingly the question arises as to how this approach can be compared with previous studies which demonstrate a visible colocalization of AChRs and α-DG in muscle cells stimulated by nerve terminals [ 19 ] or agrin [ 4 20 26 27 ] . First we note that the present results do support a significant colocalization of the two molecules in agrin stimulated cells as compared to controls (Figure 5), in general agreement with previous findings.
These effects on colocalization appear to be additive, as did the overall stimulation of AChR expression (Figure 2A).
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