Words similar to colocalization
Example sentences for: colocalization
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Figure 3) that there is less perfect colocalization of α-DG within AChR aggregates in the present study than reported previously (see for example [ 4 ] Figure 9 for a comparable study using Xenopus muscle cell cultures).
Tomographic analysis was chosen because it enables quantitative three-dimensional examination of fine structure within the relevant mitochondrial domains in semi-thick sections and thereby facilitates accurate representation of the sometimes complex membrane topology of this organelle [ 11 12 ] . Immunoelectron tomography is ideal for testing the independence of two types of labels, or label and structural component (as employed in this study), and their deviation from independence - colocalization or mutual inhibition - because it allows true 3-D distances to be measured.
We were able to localize the components of this trimolecular complex to the synovial lining layer in consecutive tissue sections, a finding that is consistent with their colocalization.
Accordingly the question arises as to how this approach can be compared with previous studies which demonstrate a visible colocalization of AChRs and α-DG in muscle cells stimulated by nerve terminals [ 19 ] or agrin [ 4 20 26 27 ] . First we note that the present results do support a significant colocalization of the two molecules in agrin stimulated cells as compared to controls (Figure 5), in general agreement with previous findings.
We report here an analysis of the 3-D distances of immunogold-labeled tBid from contact sites on the periphery of liver mitochondria that strongly supports the colocalization of the two.