Words similar to cognate
Example sentences for: cognate
How can you use “cognate” in a sentence? Here are some example sentences to help you improve your vocabulary:
The nuclear receptor (NR) family comprises 48 structurally related transcription factors, many of which require their cognate ligand for activity [ 1 2 3 ] . The NRs regulate transcription by binding to response elements in the promoters of target genes and acting as scaffolds for the assembly of large coactivator and corepressor complexes [ 4 ] . NR coactivators include the p160s (including GRIP1/TIF-2, SRC-1 and AIB1/ACTR/pCIP).
The A326S mutation of α i1 and A366S mutation of α s (cognate to the α i2 A327S used in this study) were shown to cause greatly decreased affinity for GDP [ 9 10 ] . Defective binding of GDP leads to more Gα in the empty state (no bound guanine-nucleotide), and this form of Gα is rapidly denatured in vitro , as shown for α s A366S and α i1 A326S [ 9 10 ] . Moreover, α s A366S was demonstrated to undergo rapid degradation (t 1/2 < 1 h) in stably transfected cells [ 9 ] . The same mutation in α t has also been shown to greatly decrease guanine-nucleotide binding [ 5 22 ] . Additional amino acids in the critical β6-α5 loop are important for maintaining Gα integrity [ 7 ] .
So, before we fault St. Jerome for a blunder, let us consider that so impressive a linguistic scholar as he may have chosen to give Moses horns deliberately by using cognate imagery he understood to stand for dignity and power.
At low concentrations of cognate antigen, the ratio measured for replicate spots typically showed increased dispersion, as with anti-MEKK3 and anti-SIN, and in some cases the ratio could not be measured (that is, the Cy5 signal was below background).
In both protocols, the number of tags is reported to be proportional to the abundance of cognate transcripts in the tissue or cell type used to make the cDNA library.
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