Words similar to cochlear
Example sentences for: cochlear
How can you use “cochlear” in a sentence? Here are some example sentences to help you improve your vocabulary:
The long term retention of afferents in the cochlear apex in the absence of any apparent differentiation of hair cells raises hopes for cochlear implants in deaf-born children.
Other factors, such as GDNF [ 11 40 ] need to be investigated in their expression in these mutants and their functional role needs to be assessed, in particular in the cochlear apex.
Mutations in TMC1 are responsible for the autosomal dominant human hearing disorder DFNA36 and for the recessive deafness DFNB7/11 [ 5 ] ; the corresponding murine gene Tmc1 also causes deafness in the mutant mouse strains Beethoven ( Bth ) and deafness ( dn ) [ 6 ] . Bth / Bth mice display altered potassium currents in early postnatal cochlear hair cells, in particular Ik,n and Ik,f currents appear to be depressed [ 10 ] . This observation led to the hypothesis that Tmc1 may participate directly or indirectly in regulating the permeability of potassium channels [ 10 ] . Because of the high level of conservation of the amino acid sequences among the eight mammalian TMC proteins (Figure 1, Additional file 1), we speculate that other TMC proteins may as well be modifiers of ion channels or transporters.
The first set of genes, transmembrane cochlear expressed genes 1 and 2 ( TMC1 ) and TMC2 [ 5 ] were found in a search for mutations causing dominant and recessive deafness in human and mouse [ 5 6 ] . Mutations in the second pair of genes, EVER1 and EVER2 , are linked to epidermodysplasia verruciformis that is associated with an increased susceptibility to infection with some human papillomaviruses causing a high risk of skin carcinoma [ 7 ] . We noticed that the proteins encoded by these genes are homologous, which raised our interest in testing whether the genome accommodates additional related genes.
MX generated the null mutation, bred all the mice used for this study and generated the statistical data and the immunocytochemical data with MyoVII, AM conducted the tract tracing studies of cochlear afferents and helped with the histological analysis and assembly of image plates, UP carried out the in situ hybridization for neurotrophins and assembled the plates for these data, BF wrote the manuscript, carried out most of the neuronal tracing and immunocytochemistry for acetylated tubulin and data presentation.
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