Words similar to co-repressor
Example sentences for: co-repressor
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Runx1 orthologues contain 3. CiRunt contains 5 exons downstream of the Runt domain, while CeRun contains 4. In vertebrates at least, the multiplicity of downstream exons is reflected in a large variety of alternatively spliced transcripts that give rise to multiple protein isoforms that differ in the C-terminal sequences appended to the Runt domain [ 12 13 ] . It is important to note that the C-terminal exon of all Runx genes identified to date encodes the amino acid sequence VWRPY (or the functionally equivalent IWRPF in the case of C. elegans ), which acts as a recruitment motif for the co-repressor Groucho/TLE [ 3 ] . This motif is at the C-terminus within the 3'-most exon of all of the genes, possibly with the exception of CiRunt (where the open reading frame apparently continues beyond the VWRPY in the genome sequence), and was used in our analysis to identify the C-terminal exons of previously uncharacterised Runx genes.
One of the top scoring modules is the hunchback central stripe module, other particularly interesting hits are in the intron of knirps and 18 kb upstream of hairy outside the known regulatory region, and proximal to emc, a known transcriptional co-repressor.
One way by which Smad7 can inhibit TGFβ-dependent gene expression is by blocking phosphorylation, and, hence, nuclear import of Smad3 and Smad2 [ 23 ] . More recent data showing that Smad7 is able to interact with histone deacetylases suggest an additional role for Smad7 as a transcriptional co-repressor [ 50 ] . Thus, Smad7 might interfere directly with Ese-1/Esx gene transcription.
NCoR, nuclear receptor co-repressor
GAL1, GAL4, SUC2 and MAL62, and to effect transcriptional repression by interacting with the co-repressor complex Ssn6-Tup1 [ 6, 7, 8].
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