Example sentences for: co-receptor

How can you use “co-receptor” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In addition, LRP6 has been reported to bind Wnt-1 and to associate with Fz in a Wnt-dependent manner [ 8 ] . Taken together, these results support a co-receptor model: upon exposure to Wnts, LRP5 or LRP6 forms a complex with Wnt and Fzs, transducing the Wnt signal downstream to stabilize cytoplasmic β-catenin.

  • Mis-regulation of Wnt signaling leads to the development of several human cancers, including colon carcinomas and melanoma [ 1 ] . Canonical Wnt signaling initiates in the binding of a Wnt ligand to its cell surface receptor, members of the frizzled gene family, along with the co-receptor LRP5/6 [ 2 3 ] , leading to changes in the activities of cytoplasmic effectors resulting in the stabilization of beta-catenin protein.

  • For instance, mRNA for the neuropeptide Y-like receptor (Acc# X71635), which was up-regulated in Tat expressing cells, was initially discovered as a G-protein coupled neuropeptide Y receptor, and later found to be homologous to the co-receptor CCR5 needed for HIV-1 infection of monocyte/macrophage cells.

  • These genes belong to receptor, co-receptor, and co-activator pathways that are part of serine/threonine receptor tyrosine kinase, Ras/Raf/MEK/ERK (MAPK) cascade, which control proliferative and/or differentiation signals.

  • The increase in viral titer peaked after some 18 days of infection with the R5 virus, further implying that the CCR5 co-receptor allowed a better selection of R5 virus in Tat expressing cells.


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