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Example sentences for: clendo

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TNFα reduces viability of CLENDO cells
TNFα elevates ceramide in CLENDO cells, whereas sFasL elevates ceramide in primary luteal steroidogenic cells [ 26 ] . Ceramide treatment induces apoptosis in both cell types, suggesting that the sphingomyelin pathway may be a common mediator of cell death among distinct cell types within the CL.
To confirm specificity of ceramide in triggering CLENDO cell death, cultures were treated with sphingosine-1-phosphate (S1P; 10 or 50 μM; BioMol; Plymouth Meeting, PA) for 48 h.
Since TNFRSF induces cell death by causing an efflux of glutathione (GSH) in other cell types [ 42 ] we sought to determine if pretreatment of CLENDO cells with GSH would attenuate lethality associated with TNFα treatment.
CLENDO cells treated with TNFα for 12 h showed no significant difference in the number of non-apoptotic cells compared with the 72 h untreated control.