Words similar to clb
Example sentences for: clb
How can you use “clb” in a sentence? Here are some example sentences to help you improve your vocabulary:
Cdc5 is required for full activation of the Dbf2-Mob1 protein kinase complex [ 15 16 17 ] , and has been proposed to impinge on the MEN both upstream and downstream of Tem1 [ 15 16 17 18 ] . During exit from mitosis, Cdc5 is required for Clb2 destruction, and similar to over-expression of Cdc14 [ 3 ] , induction of Cdc5 triggers precocious Clb2 degradation in pre-anaphase cells [ 19 20 ] . In addition to its role in exit from mitosis, Cdc5 has other functions during mitosis in budding yeast.
Interestingly, Clb2 was rapidly and efficiently degraded upon reversal of the cdc15-2 block regardless of whether cycloheximide was present (Figure 1) although both cytokinesis and cell separation require protein synthesis [ 42 ] . This observation suggests that the exit from mitosis in budding yeast may be controlled by mechanisms fundamentally similar to those employed by animal cells, which proceed through mitosis with highly condensed, transcriptionally silent chromosomes.
inactivation of Clb/Cdc28 via proteolysis of Clb2) in the absence of new gene expression, we evaluated the turnover of Clb2 in cells released from a cdc15-2 arrest in the presence of cycloheximide.
dbf2Δ [ 22 7 ] . To address if production of new proteins is essential for exit from mitosis, we examined the effects of the protein synthesis inhibitor cycloheximide on Clb2 degradation, a key aspect of this process.
Sic1) normally facilitates the exit from mitosis, it reveals that a key aspect of mitotic exit - inactivation of Cdc28 protein kinase via degradation of the mitotic cyclin Clb2 - can proceed beyond the Cdc15-dependent step without synthesis of new proteins.
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