Words similar to clb

Example sentences for: clb

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By counteracting Cdk1-mediated phosphorylations, Cdc14 activates both Hct1/Cdh1, which targets Clb2 for degradation [ 3 4 5 ] , and Swi5, which turns on the transcription of Cdk1 inhibitor Sic1 [ 6 3 ] . Degradation of Clb2 and accumulation of Sic1 act in concert to eliminate mitotic Cdk activity, which is required for exit from mitosis [ 7 ] . Thus, elucidating how Cdc14 is regulated holds the key to understanding how cells exit mitosis.
Ectopic release of Cdc14 might contribute to the proliferation block and Clb2 degradation caused by induction of GAL-CDC5(DB▲) [ 19 20 ] . Overexpression of Cdc5(DB▲) also altered nucleolar structure in nocodazole-arrested cells (Figure 2B), the reason for which is not understood.
In contrast, as Tem1-depleted tab3-1 cells progressed through mitosis, Clb2 was almost completely degraded and Sic1 accumulated to high levels (Figure 3B, right panels).
During exit from mitosis, a TEM1/CDC15 -dependent signal frees Cdc14 from the nucleolus and allows it to promote inactivation of Clb/Cdc28 [ 15 17 19 ] . The fact that both Net1 and Cdc14 are directly involved in exit from mitosis validates the effectiveness of the tab screen and heightens the potential value of the uncharacterized tab mutants.
Importantly, tab mutants from both classes appeared to bypass mitotic arrest in Tem1-depleted cells by enabling degradation of Clb2 and accumulation of Sic1 - two hall-marks of mitotic exit (Figure 3; [ 15 18 ] ).