Words similar to clb

Example sentences for: clb

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Sic1) normally facilitates the exit from mitosis, it reveals that a key aspect of mitotic exit - inactivation of Cdc28 protein kinase via degradation of the mitotic cyclin Clb2 - can proceed beyond the Cdc15-dependent step without synthesis of new proteins.
Ectopic release of Cdc14 might contribute to the proliferation block and Clb2 degradation caused by induction of GAL-CDC5(DB▲) [ 19 20 ] . Overexpression of Cdc5(DB▲) also altered nucleolar structure in nocodazole-arrested cells (Figure 2B), the reason for which is not understood.
Detection of proteins from crude yeast extracts was as described [ 15 ] . The following primary antibodies were used in immunoblotting: anti-Sic1 (1:8000), anti-Clb2 (1:2500), anti-Cdc28 (1:3000), and 12CA5 (directed against the haemagglutinin (HA) epitope; 1:1000, with 0.5 M NaCl).
In the presence of cycloheximide, Sic1 accumulation was abolished, but Clb2 degradation still occurred with apparently normal kinetics (Figure 1, lanes 5-8 and 9-12).
Interestingly, Clb2 was rapidly and efficiently degraded upon reversal of the cdc15-2 block regardless of whether cycloheximide was present (Figure 1) although both cytokinesis and cell separation require protein synthesis [ 42 ] . This observation suggests that the exit from mitosis in budding yeast may be controlled by mechanisms fundamentally similar to those employed by animal cells, which proceed through mitosis with highly condensed, transcriptionally silent chromosomes.