Words similar to clathrin-coated

Example sentences for: clathrin-coated

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The phosphorylated beta-2 receptor enhances the binding of beta-arrestin, which not only uncouples the receptor from the signal transduction process but also serves as an adapter protein that mediates entry into the internalization pathway [ 5 ] , as well as serving as a platform for additional signaling pathways [ 6 ] . The mechanisms of beta-2 adrenergic receptor down-regulation appear to involve both an increase in the rate of degradation of the receptor as well as a decrease in the levels of beta receptor mRNA [ 7 ] . Down-regulation of the beta-2 receptor is, in part, due to trafficking of the beta-2 receptor to lysosomes via the clathrin-coated pit endosomal pathway [ 8 9 ] .
Sisodia and colleagues [39] demonstrated that arrest of APP endocytosis from the plasma membrane by deletion of its NPXY clathrin-coated vesicle targeting sequence [40,41] can dramatically stimulate sAPP α shedding, presumably by extending the half-life of co-localized α-secretase and APP on the plasma membrane.
It is composed of a cytoplasmic ATPase domain called V 1 that contains VhaSFD and other subunits, and a multisubunit membrane-channel component called V 0 . The vacuolar ATPase is involved in the acidification and energization of organelles such as Golgi-derived vesicles, clathrin-coated vesicles, synaptic vesicles and lysosomes.