Words similar to citramalate
Example sentences for: citramalate
How can you use “citramalate” in a sentence? Here are some example sentences to help you improve your vocabulary:
The citramalate pathway for conversion of pyruvate to 2-ketobutyrate involves a carbon-chain elongation mechanism that uses an initial step of condensation with acetyl-CoA, followed by rearrangement, oxidation and elimination of a carbon to produce a keto acid differing from the original substrate by the presence of an additional carbon.
A few tracer studies in the older literature have indicated derivation of α-ketobutyrate from pyruvate rather than from threonine [ 32, 33], and (R)-citramalate synthase activity has been shown recently in M. jannaschii (MJ1392) [ 34].
These analogous steps in different pathways were originally used in formulating the recruitment hypothesis for evolutionary acquisition of new function [ 37], and it is interesting that the citramalate synthase gene shown in M. jannaschii had previously been annotated as α-isopropylmalate synthase (which catalyzes the initial step of leucine biosynthesis).
It appears likely that α-ketobutyrate is generated instead by the 'pyruvate' pathway in which citramalate is generated as the initial intermediate.