Words similar to citramalate
Example sentences for: citramalate
How can you use “citramalate” in a sentence? Here are some example sentences to help you improve your vocabulary:
It appears likely that α-ketobutyrate is generated instead by the 'pyruvate' pathway in which citramalate is generated as the initial intermediate.
These analogous steps in different pathways were originally used in formulating the recruitment hypothesis for evolutionary acquisition of new function [ 37], and it is interesting that the citramalate synthase gene shown in M. jannaschii had previously been annotated as α-isopropylmalate synthase (which catalyzes the initial step of leucine biosynthesis).
A few tracer studies in the older literature have indicated derivation of α-ketobutyrate from pyruvate rather than from threonine [ 32, 33], and (R)-citramalate synthase activity has been shown recently in M. jannaschii (MJ1392) [ 34].
The citramalate pathway for conversion of pyruvate to 2-ketobutyrate involves a carbon-chain elongation mechanism that uses an initial step of condensation with acetyl-CoA, followed by rearrangement, oxidation and elimination of a carbon to produce a keto acid differing from the original substrate by the presence of an additional carbon.