Words similar to cip
Example sentences for: cip
How can you use “cip” in a sentence? Here are some example sentences to help you improve your vocabulary:
Conversely, introduction of full-length BRCA1 by retrovirus-mediated gene transfer inhibited growth of breast and ovarian cancer cell lines in both in vitro and in vivo experiments [ 51], and transfection of BRCA1 into colon cancer cells inhibited new DNA synthesis by 50% in addition to inhibition of S-phase progression, possibly through direct transactivation of the cell cycle inhibitor p21 WAF1/CIP1[ 49].
Collectively, they have established that the expression of cyclin A and cyclin D, in combination with the activity of the cyclin-dependent kinase inhibitors p21 Cip1and p27 Kip1, is a crucial determinant of anchorage-dependent cell growth culture [ 27 28 29 30 31 32 ] . However, while the above elements clearly are essential executioners of cell cycle progression, it is conceivable that other elements, directly or indirectly, might be involved in anchorage-dependent growth control as well.
A characteristic phenotype of tumorigenic cells is their ability to grow anchorage-independently in suspension culture, or embedded in soft agar, without the need for attachment to the surface of a cell culture dish [ 25 26 ] . A flurry of papers has established a close link between anchorage-independent growth and the activity of several components of the cell cycle machinery, such as various cyclins, cyclin-dependent kinases (CDKs), and the CDK inhibitors p21 Cip1and p27 Kip1 [ 27 28 29 30 31 32 ] . There are indications that PTEN may be involved in these processes as well.
PFD, pelvic floor disorders; p27, p27 kip1; PBS, phosphate-buffered saline; CL, corpus luteum or corpora lutea; cdk, cyclin-dependent kinase; p21, p21 Cip1/WAF1.
Instead, CIP8, an AtCOP1 interacting RING-H2 finger protein, is found to ubiquitinate HY5 in vitro [ 50 51 ] . Therefore, it is possible that COP1 may recruit other RING finger proteins, such as CIP8, to mediate the ubiquitination of specific substrates.
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