Words similar to cidofovir

Example sentences for: cidofovir

How can you use “cidofovir” in a sentence? Here are some example sentences to help you improve your vocabulary:

The natural phenomenon of spontaneous mutation, which occurs in the absence of drug selection, results in the accumulation of approximately six to eight TK-deficient variants per 10 4plaque-forming viruses in virus populations that have never been exposed to selective pressure [ 6 10 12 ] . Furthermore, HSV-2 clinical isolates were shown to have a higher frequency of spontaneous mutations resistant to ACV and PCV, approximately 30-fold, compared to HSV-1 isolates, and the majority of these mutations are in tk . Consistent with this observation, HSV-2 strains also exhibited approximately a 20- to 80-fold higher spontaneous mutation rate to cidofovir (HPMPC), an inhibitor of HSV Pol, resistance compared with HSV-1 [ 21 ] . Therefore, these naturally-occuring mutations are not unique to tk and TK substrates as detected with antiviral agents ACV and PCV, but were extended with the direct Pol inhibitor, HPMPC, to other loci, most likely pol .
For example, cidofovir, an acyclic nucleoside with activity against a variety of DNA viruses, used clinically in some instances [ 39 ] , has been shown to be effective against a number of poxviruses with the following EC 50 values: 2.3 μM (camelpox), 46.