Words similar to chronically
Example sentences for: chronically
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Stimulation from human IL-1β was then provided by addition of recombinant IL-1β protein or by co-culture with fibroblasts genetically engineered to constitutively secrete high levels of human IL-1β [ 21 ] . Using prostaglandin E 2 (PGE 2 ) levels in conditioned media as a readout of IL-1 stimulation in the respective cultures, protection from IL-1 stimulation by each method was evaluated under static and dynamic culture conditions, the latter of which were designed to resemble more closely the circumstance of an arthritic joint in which IL-1 is chronically produced.
The increased concentration of ABP present in the testes of TG mice (see Joseph et al . [ 25 ] ) will chronically reduce the concentration of intra-testicular free T available for interaction with androgen receptor (AR) and other molecular targets.
VEGF is a 45 kDA heparin-binding homodimeric glycoprotein with a predominant specificity to vascular endothelial cells [ 4 5 6 7 ] . Recent investigations demonstrate that VEGF increases vascular permeability [ 4 ] , endothelial cell proliferation in vitro [ 8 ] , and angiogenesis in vivo [ 9 ] . We have previously demonstrated that VEGF mRNA is upregulated in rat gastrocnemius muscle following 1 hour of acute submaximal treadmill exercise [ 10 ] , in dog gastrocnemius muscle following 1 hour of electrical stimulation [ 11 ] , and in human vastus lateralis following 30 min of one-legged knee extension exercise at 50% maximal capacity [ 12 ] . Other studies show similar upregulation of VEGF mRNA in chronically electrically stimulated rat skeletal muscle [ 13 14 ] , and in human vastus lateralis following 45 min of one-legged knee extension exercise [ 15 ] .
Several small trials of STIs in chronically infected patients were carried out [4], buoyed by the reasonable desire of patients for respite from the unpleasant side effects of the drugs.
And now, as if the chronically stupid Christopher and the paranoid Uncle Junior and the wily, batty Livia weren't enough to make Tony strung out, we've got Richie Aprile.
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