Words similar to chimpanzee
Example sentences for: chimpanzee
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3 and the fact the CHRNA7 duplication appeared polymorphic in the human population [ 17 ] . This hypothesis deserved consideration in this study, as the site of duplication of the CHRNA7 locus in the human genome may correspond to the pericentric inversion breakpoint, and the high sequence homology noted between the donor and duplicated CHRNA7 loci does not establish the human-specificity of the CHRNA7 duplication, as gene conversion may also maintain high sequence homology of duplicated segments [ 26 27 ] . Thus, we tested the chimpanzee genome by Southern genomic analysis for the presence of the CHRNA7 duplication which revealed this duplication is most likely human-specific and therefore did not contribute to the pericentric inversion in chimpanzee (Figure 5).
The annotated chimpanzee exon sequences have been submitted to GenBank with the accession numbers AF179218, AF179219 and AF179220.
To determine the evolutionary age of the CHRNA7 duplication with respect to the human/chimpanzee divergence, we performed a genomic Southern blot using DNA extracted with the PureGene DNA isolation kit (Gentra Systems, Minneapolis, MN).
Sequencing DNA from mouse, chimpanzee and baboon samples
The karyotypes of humans and the African and Asian great apes are remarkably well conserved, with relatively few large-scale chromosomal changes among these species despite the considerable phenotypic and biological differences between hominoids [ 1 2 3 ] . This conservation is particularly relevant in comparisons between the human ( Homo sapiens ; HSA) and common chimpanzee ( Pan troglodytes ; PTR) genomes, for in order to completely ascertain the evolution of our own lineage it is necessary to understand what differentiates us at the genomic level from our closest relatives.
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