Words similar to chimpanzee
Example sentences for: chimpanzee
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On the basis of the findings of Pujana et al ., the GLP/LCR15 duplicon is present at multiple regions of human genomic instability [ 21 ] . In addition, the GLP/LCR15 duplicon was shown by Gilles et al . to be polymorphic in the human population - showing that these sequences have considerable intraspecific plasticity [ 18 ] . The GLP/LCR15 duplication family has expanded over the last 20 million years of primate evolution, before the divergence of the great ape lineages, resulting in a multitude of copies (estimated at 27) present at multiple sites along chromosome 15, providing the conditions required for rearrangements driven by nonallelic homologous recombination (NAHR) [ 18 19 21 27 ] . We have begun an investigation of the organization of this region within the chimpanzee lineage.
These additional hybridizations were performed on human and chimpanzee material only.
Upon hybridization of this probe to a panel of human, pygmy chimpanzee, common chimpanzee and gorilla genomic DNAs, two bands were observed in the human sample and a single band was noted in all great ape species, providing further evidence that the CHRNA7 duplication was specific to humans and was not present at the time of the pericentric inversion event in the chimpanzee genome.
It should be noted that the inversion, although primarily characterized in the common chimpanzee ( Pan troglodytes ) was also observed in the pygmy chimpanzee ( Pan paniscus ) thus dating the inversion event more precisely to an interval of 2-5 million years ago (data not shown).
Consequently, we performed comparative FISH in human and chimpanzee using multiple BAC clones that flanked RP11-40J8 in the November 2002 build of the human genome (Figures 3, 4).
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