Words similar to cell-surface
Example sentences for: cell-surface
How can you use “cell-surface” in a sentence? Here are some example sentences to help you improve your vocabulary:
In light of recent developments in understanding the biology of Toll-like receptors, the NFκB-dominated responses we observe fit well within a model in which undifferentiated, subconfluent Caco-2 cells can recognize Gram-positive cell-surface moieties and induce what is termed an 'innate immune response'.
Previously we have examined the protein-protein interactions of proHB-EGF with the cell-surface CD9 antigen [ 9 ] . The CD9 antigen is found on a wide variety of tissue and cell types and has been reported to be involved in such cellular processes as B-cell development, cell metastasis, platelet activation and adhesion, and cell motility [ 14 15 ] . CD9 antigen is a member of the tetraspanin superfamily and consists of two extracellular domains sandwiched between four highly-conserved hydrophobic transmembrane domains [ 14 15 ] . The second extracellular domain (75-130 amino acids) is larger than the first extracellular domain (20-27 amino acids).
Hyal-1 is a candidate tumor suppressor [ 5 18 ] , although it enhances extravasation and metastasis of prostate cancer cells [ 3 ] . Also, mutations in Hyal-1 may contribute to the pathogenesis of a lysosomal disorder, mucopolysaccharidosis IX [ 19 ] . Hyal-2 is a lysosomal protein, which is active at low pH [ 20 ] . This protein is also known to be a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus [ 21 ] .
The tetraspanins are a family of cell-surface proteins with four transmembrane domains, two extracellular loops, and conserved cysteine residues at key positions in the second extracellular loop [ 1 ] . They facilitate a wide array of functions, including cell activation, differentiation, adhesion, morphological changes, and motility, which may all relate to the promiscuous associations of these molecules with integrins and other signaling proteins within the cell membrane and the cytoskeleton.
Ultimately, the integral cell-surface metalloproteinases ADAM-10 and ADAM-17/TACE were found to underlie α-secretase-type ectodomain shedding [3,46].
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