Words similar to cddo

Example sentences for: cddo

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We found that Bcl-3 was inducible with IL-1 in human primary chondrocytes, and that CDDO significantly inhibited this expression (Fig.
Naturally occurring triterpenoids, such as ursolic acid, have been found to have mild anti-inflammatory effects [ 18 27 ] . These have been improved with the development of synthetic triterpenoids such as CDDO, offering a potential therapeutic tool for the treatment of arthritis and other diseases [ 19 20 21 ] . Furthermore, it has been reported that CDDO at high doses (5-10 μM) can have pro-apoptotic effects, ideal for the treatment of leukemia but of concern with regard to chondrocyte cell death [ 25 26 ] . However, we found that CDDO, at concentrations that decrease MMP-1 and MMP-13 expression (namely 300 nM and 1 μM), did not cause cell death.
These findings make CDDO an attractive molecule to study as a potential anti-arthritic agent.
CDDO time-course in human primary chondrocytes
IL-1 induced the expression of MMP-1 and MMP-13, and these were significantly inhibited when the cultures were pretreated with CDDO for 24 hours, the respective decreases being 55% for MMP-1 ( P < 0.1) and 66% for MMP-13 ( P < 0.01).