Words similar to caveolin-
Example sentences for: caveolin-
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Patients with autosomal dominant limb girdle muscular dystrophy type 1C, caused by mutations in caveolin-3 [ 19, 20], or autosomal recessive LGMD2B, caused by mutations in dysferlin, show normal dystrophin and sarcoglycan-sarcospan complex staining patterns [ 21].
A similar vascular hyper-responsiveness has been noted in caveolin-1 knock-out mice [ 25 26 ] raising the possibility that the accumulation of Gb 3 results in over-activity of uncoupled endothelial nitric oxide synthase within endothelial cell caveolae generating superoxide and other reactive oxygen species [ 27 ] . The latter may have a vasodilatatory effect [ 28 ] . Predominance of vascular abnormalities in the vertebro-basilar system in Fabry disease suggests fundamental biologic differences between the anterior and the posterior circulation.
These microdomains recruit an impressively large number of cellular proteins and regulatory molecules such as Rho, profilin, actin, caveolin-1, CD44, and phosphotidylinositol 4,5-biphosphate (PIP2), and have been shown to be important in a variety of cellular functions in health and disease [ 27 28 29 ] . Recently, a number of pathogens have been shown to hijack these sites for their entry, exit, and assembly; such agents include many RNA viruses such as HIV, measles virus, influenza virus, and RSV [ 29 30 31 32 33 ] . In a very recent study [ 34 ] , filamentous RSV was confirmed to exit through membrane microdomains, and immunological analysis placed RSV proteins F, N, and P at these sites.
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