Words similar to cas
Example sentences for: cas
How can you use “cas” in a sentence? Here are some example sentences to help you improve your vocabulary:
Thus, CAS was as potent a transcriptional activator as Gal4 in this growth assay.
Cas is a protein which migrates with an apparent mass of approximately 130 kDa, with a N-terminal SH3 domain, a central substrate domain (SD) with up to 15 tyrosines which can be phosphorylated, a C-terminal region with a proline-rich region, and two tyrosine phosphorylation sites capable of binding Src kinases (Src binding domain (SBD)) [ 6 18 ] . The latter SBD domain regulates the ability of Src to activate the serum response element, as well as in the phosphorylation of the SD of Cas by Src [ 18 19 20 ] . The substrate domain controls adhesion and migration and the majority of the tyrosines within this domain are of the sequence YQXP (5) or YDXP (10), which when phosphorylated, bind to the adaptors c-crk, nck and AND-34 [ 16 21 22 23 ] . The importance of these molecules in Cas function is unclear, however c-crk seems to be critical in the regulation of adhesion and migration mediated by Cas.
Initially, we expressed the Src KM/Cas(SD) (entire Cas SD) in Cos-7 cells alone, or along with wild type (WT) v-crk, or v-crk SH2 or SH3 mutants and assayed for tyrosine phosphorylation and association by co-immunoprecipitation (Fig.
Tyrosine phosphorylated Cas SD acts as a decoy for v-crk and endogenous c-crk
Expression of the Cas(SD) or the Src KM/Cas(SD), fusion did not result in any increase in total phosphotyrosine containing proteins nor in the tyrosine phosphorylation of the Cas SD (data not shown and see Fig.
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