Words similar to carvedilol
Example sentences for: carvedilol
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In contrast to non-treated DCM hearts, myocardial tissue sectionsprepared from hearts from animals treated with carvedilol showeda significant reduction in the numbers of TUNEL-positive myocytenuclei.
Effect of Carvedilol on Cardiac Myocyte Apoptosis
We studied two dosages (pharmacologicaland non-pharmacological) as a difference in dose-dependency forcardiac function improvement has previously been demonstrated byus with another non-selective beta-blocker [ 18 ] .Furthermore, we wanted to determine if carvedilol might exert beneficialeffects independent of heart rate effects.
Of particular interestis the use of carvedilol [ 12 13 14 15 16 ] .Carvedilol is a novel multiple-action neurohormonal antagonist.Its primary activities are nonselective β-adrenoceptor blockade,vasodilatation (mediated through α1-adrenoceptor blockade), andantioxidant activity [ 12 ] . In many clinical studies,carvedilol has been shown to improve left ventricular function andsymptoms in patients with ischemic heart disease or idiopathic dilatedcardiomyopathy [ 13 14 15 16 ] andto dramatically reduce mortality [ 17 ] .However, it remains unclear how carvedilol improves ventricular functionin heart failure.
, carteolol, had normal calcium cycling, normal myocardial energetics,normal β 1 receptor density as well as regression of myocytehypertrophy and reduced connective tissue content [ 18 ] . Furthermore, administration of carteolol hasbeen reported to prevent the development of virally induced cardiomyopathyin a murine model [ 25 ] . In a canine modelwith left ventricular dysfunction produced by multiple sequentialintracoronary microembolizations, long term treatment with metoprolol,a β 1 -selective blocker, has been reported to preventthe progression of LV systolic dysfunction and LV chamber dilatation [ 26 ] . Similarly, our present findings onthe effect of carvedilol indicated improvement of left ventricularfunction and smaller LV volumes.
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