Words similar to cardiotoxicity
Example sentences for: cardiotoxicity
How can you use “cardiotoxicity” in a sentence? Here are some example sentences to help you improve your vocabulary:
Vacuole formation in the cardiac myocytes has been used as a marker of cardiotoxicity [ 13 ] . The mean percent of cardiac myocytes with one or more vacuoles in the subendocardial myocytes of the left ventricle was significantly (p < 0.05) higher in mice fed the sE supplement (Fig.
It should be realized that these observations are suggestive of cardiotoxicity but are not definitive.
Evidence for cardiotoxicity, as observed in this study, was not expected as supplementation with vitamin E at extremely high doses gave no significant indications of harmful side-effects in animals or in humans [ 18 25 ] . Perhaps vitamin E supplementation acts to inhibit lipid peroxidation but at the same time acts to down regulate other protective antioxidant systems as suggested by the antioxidant enzyme gene expression data in Table 4. If gene expression levels in Table 4reflect antioxidant enzyme activity, then an increase in SOD and decrease in GPX without an increase in CAT would result in accumulation of inorganic and organic peroxides and hydroperoxides that can react with Fe 2+to yield highly reactive free radical products that can damage cellular proteins and DNA as well as lipids.
Early studies suggested that vitamin E lessened the cardiotoxic effects of DOX chemotherapy [ 26 ] whereas other studies indicate potentiation of DOX induced cardiotoxicity [ 27 28 ] . Shinoyawa et al.
Based on this indication of cardiotoxicity, the remaining portion of the heart that had been snap frozen in liquid nitrogen at the time of sacrifice was used to look for differences in expression of antioxidant genes using quantitative RT PCR methodology.
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