Words similar to cardiolipin
Example sentences for: cardiolipin
How can you use “cardiolipin” in a sentence? Here are some example sentences to help you improve your vocabulary:
As previously noted, contact sites are purported to have a unique lipid environment that is rich in cardiolipin.
This distinction suggests that tBid might localize to contact sites because of the arrangement of cardiolipin there.
Indeed it was found that the targeting of tBid to mitochondria-like membranes occurs in the absence of proteins, yet depends upon cardiolipin being in a possibly unique structure as opposed to free cardiolipin [ 9 ] . The requirement for a specific cardiolipin structure that is likely defined by the contact site is consistent with our observation that no gold particles were found in regions stripped of the outer membrane exposing the cardiolipin-rich inner membrane.
Recently, we demonstrated that the targeting of the pro-apoptotic protein tBid to mitochondria depends upon the presence of the mitochondria-specific lipid cardiolipin in a possibly unique structure [ 9 ] . Cardiolipin has a defined distribution pattern within mitochondria [ 10 ] . It is found in high concentrations throughout the inner membrane, including at contact sites where the inner membrane and outer membrane interact.
1and 2) and was shown to destabilize lipid membranes in vitro (along with Bax) by increasing the permeabilization of artificial liposomes [ 25 26 ] . Therefore it is possible that tBid can bind to the cardiolipin rich contact site membranes and destabilize them by inducing Bax or Bak to oligomerize.