Words similar to cardiolipin
Example sentences for: cardiolipin
How can you use “cardiolipin” in a sentence? Here are some example sentences to help you improve your vocabulary:
As previously noted, contact sites are purported to have a unique lipid environment that is rich in cardiolipin.
The presence of cardiolipin has been implicated in the function of numerous mitochondrial proteins including, sites I and III of the electron transport chain, the adenine nucleotide transporter, the protein translocation machinery, and the localization of mitochondrial creatine kinase [ 19 20 21 22 ] .
Recently, we demonstrated that the targeting of the pro-apoptotic protein tBid to mitochondria depends upon the presence of the mitochondria-specific lipid cardiolipin in a possibly unique structure [ 9 ] . Cardiolipin has a defined distribution pattern within mitochondria [ 10 ] . It is found in high concentrations throughout the inner membrane, including at contact sites where the inner membrane and outer membrane interact.
For example, there was consistently more AA accumulating in various hepatic PL than in the hippocampus following AA feeding; and more DHA accumulated in hepatic cardiolipin (CL) than in hippocampal CL, whereas the reverse was true for phosphatidylserine/phosphatidylinositol (PS/PI).
The loss of cytochrome c causes a break in the electron transfer chain resulting in the production of reactive oxygen species [ 31 ] . Reactive oxygen species are known to cause the oxidation and loss of function of many lipids including cardiolipin [ 20 ] . Finally, caspases activated downstream of cytochrome c release have been implicated in mitochondrial damage [ 29 ] . It appears likely that the cumulative damage of these agents could lead to the irreversible loss of mitochondrial membrane integrity and structure.
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