Words similar to cardiacmyocytes
Example sentences for: cardiacmyocytes
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Loss of cardiacmyocytes has been suspected to be a feature of the cardiomyopathicprocess that contributes to progressive decline in left ventricularfunction and the development of congestive heart failure [ 29 ] . Evidence supporting the concept ofmyocyte apoptosis occurrence and contribution in the progressionof heart failure has been obtained from a variety of observations,including in vitro studies, experimental animal modelsof cardiac dysfunction, and studies on cardiac tissue obtainedfrom patients with end-stage heart failure [ 5 7 8 9 29 ] .
Both in animal and human studies of heart failure, β-adrenergicblockade intervention appears to have beneficial effects on cardiacmyocyte function [ 1 23 24 ] . Of particularimportance, studies using carvedilol have shown remarkable improvementsin cardiac performance [ 12 13 15 16 ] andreduction in mortality in humans [ 17 ] .We have previously shown that propranolol, a nonselective β-blocker,is cardioprotective and prevents the development of heart failurein turkeys when given concurrently with furazolidone [ 21 ] . Similarly, carteolol, a nonselective β-blocker,resulted in improvement in ejection fraction, reduction in ventricularvolumes, an increase in developed pressure as well as an increasein rate of survival in our turkey model [ 18 ] . Improvementin cardiac function was associated with cellular remodeling of cardiacmyocytes.