Words similar to capsaicin

Example sentences for: capsaicin

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The oocytes were triturated according to the method described above, except for the capsaicin-present condition, where 10-20 μM capsaicin was included in the lysis buffer.
The results of these experiments are shown in Figure 3. Like for wild-type VR1 channels, capsaicin activated N604S channels in a concentration-dependent manner (Figures 3A, 3C, and 3E).
For calcium- present condition, whole oocytes were bathed in frog Ringer's solution with or without 10-20 μM capsaicin for the same duration.
The predicted topological organization consists of six transmembrane domains with a hydrophobic loop between the fifth and sixth domain which lines the ion conducting pore [ 17 ] . VR1 has been expressed heterologously in several cell lines and has intrinsic sensitivity to thermal stimuli and to capsaicin (a pungent extract of the Capsicum pepper family) [ 18 ] . VR1 does not discriminate among monovalent cations [ 19 ] ; however, it exhibits a notable preference for divalent cations with a permeability sequence of Ca 2+> Mg 2+> Na +≈ K +≈ Cs + [ 9 ] . Ca 2+is especially important to VR1 function, as extracellular Ca 2+mediates desensitization [ 20 21 ] , a process which enables a neuron to adapt to specific stimuli by diminishing its overall response to a particular chemical or physical signal.
Figure 1Adepicts a current family obtained using a saturating (4 μM) capsaicin concentration when the voltage was stepped from a holding potential of 0 mV to from -100 to +100 mV.