Words similar to capsaicin
Example sentences for: capsaicin
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The results of these experiments are shown in Figure 3. Like for wild-type VR1 channels, capsaicin activated N604S channels in a concentration-dependent manner (Figures 3A, 3C, and 3E).
Capsaicin's use in the treatment of chronic pain is due to an analgesic effect that is explained by capsaicin's action of depletion of stores of substance P from primary sensory neurons as a consequence of the reduced production of prostaglandin [ 39 60 ] . Capsaicin's antiphlogistic activity is due to the "counter-irritant effect"; which means that a local irritant effect exerts an additional more remote antiinflammatory effect [ 60 ] . This is explained by a liberation of corticoids under the influence of certain cutivisceral reflexes [ 60 ] . The counter-irritant effect on the gastric mucosa also occurs because capsaicin stimulates production of the cytoprotective prostaglandin E 2 [ 60 ] . Capsaicin produces analgesic and antiinflammatory effects because it inhibits both 5-lipoxygenase and cycoloxygenase [ 39 ] . A 10 g human ingestion of red pepper stimulated carbohydrate oxidation [ 62 ] . This may explain why the Chocó Indians used it to give their hunting dogs more "energy" [ 25 ] .
To examine the effect of calcium and capsaicin on VR1 dimer formation, four different conditions were tested.
As seen in the last two lanes of this gel, the presence of EGTA (2 mM) did not alter the formation of the VR1 dimer, whether capsaicin was or was not present in the assay - the monomer:dimer ratio did not differ from control conditions (p > 0.05, for 3 independent experiments under the same conditions).
Figure 1Adepicts a current family obtained using a saturating (4 μM) capsaicin concentration when the voltage was stepped from a holding potential of 0 mV to from -100 to +100 mV.
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