Words similar to canonical
Example sentences for: canonical
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Although most known pre-miRNAs in Drosophila , Caenorhabditis , mice and humans form relatively canonical stem-loops of around 70 to 100 nucleotides in length, plant miRNA precursors are often processed through exceptionally long stem-loops (many 150 nucleotides or longer) [ 14 15 16 ] . miR-125 is a member of the Drosophila reference set that received a low score by our informatic procedure, possibly because it may derive from an unusually long stem-loop (120 nucleotides), only a portion of which was included in the queried window.
Secondly, we showed that all members of the four yCCR4-related protein families that we have characterized contain the canonical catalytic residues and motifs of the Mg 2+-dependent endonuclease core, as well as strictly conserved yCCR4-specific residues.
As an example, we show alignments and RNA folds of the four insect orthologs of 2R:11128979, which all adopt canonical, high-scoring stem-loop structures and collectively display patterns of nucleotide divergence characteristic of genuine miRNAs (preponderance of divergence within the loop, slightly less divergence along a nonconserved arm, and perfect conservation of a putative miRNA-encoding arm) (Figure 6).
In all the available organisms, the four central protomers of the midasin polypeptide, AAA2, AAA3, AAA4 and AAA5, possess canonical Walker A and B motifs, as well as the critical Asn in sensor 1 and Arg in sensor 2 that are required for proper function in other AAA proteins [ 15 ] . The presence of these critical residues, taken together with their higher level of average sequence conservation (Table 1), suggests that the four central protomers all retain an active enzymatic function.
Unlike human and monkey AH myocilin, rabbit myocilin does not undergo canonical N-linked glycosylation due to the substitution of a serine in the analogous human N-linked glycosylation site (N57).
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