Words similar to canonical
Example sentences for: canonical
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3; see also reference [ 5 ] ). The Walker A motif GxxxxGK [T,S] and Walker B motif hhhhDExx (where h is any hydrophobic residue and x is any residue), that contain residues essential for ATP binding and hydrolysis in all P-type ATPases [ 17 ] , are present in their canonical forms in the AAA2, AAA3, AAA4, and AAA5 protomers of midasin for all the organisms in Figure 3. The Walker A motif is present also in AAA1 and AAA6, although the Walker B motif in these protomers is deviant.
This protein is not homologous to the canonical TS, but its orthologs in bacteria and archaea show an almost perfect complementary phyletic distribution (COG1351).
Similarly, the ZAS-C pentamer together with its complement form the canonical RSS heptamer palindrome "CACTGTG".
Previously identified genes regulated by Wnt signaling in this list include fibronectin [ 17 ] , IL-6 [ 18 ] , BMP-4 [ 19 ] , groucho related protein [ 20 ] , and Krox-20 [ 21 22 ] . Since Wnt-5a may couple to more than one frizzled receptor, different Wnt signaling pathways may be activated by Wnt-5a depending on the endogenous expression of various frizzled receptors [ 6 10 ] . Thus, it is possible that the gene expression pattern we identified may be due to the activation of both canonical and noncanonical Wnt signaling pathways.
Some of these variants have been independently observed by other groups: NF1ins4a-2 [ 14 15 16 ] , NF1ΔE4b [ 14 15 16 ] , NF1ΔE7 [ 15 19 ] , NF1ΔE29/E30 [ 11 ] , NF1ΔE30 [ 11 ] , NF1ΔE33 [ 16 ] , NF1ΔE34 [ 16 ] , NF1ΔE37 [ 15 16 ] , NF1ΔE43 [ 16 ] , NF1-Δ7605-7675 [ 16 ] and NF1ΔE45 [ 16 ] . Some of these transcripts increased with time or cold shock [ 14 16 ] . It has been shown that ~30 % of NF1 germline mutations result in splicing errors [ 13 20 ] . The vast majority of them are due to alterations outside the canonical AG/GT acceptor and donor splice sites.
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