Words similar to canonical
Example sentences for: canonical
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The plethora of terms reflects the difficulty of choosing a "best" canonical class term for the precancerous lesions.
As an example, we show alignments and RNA folds of the four insect orthologs of 2R:11128979, which all adopt canonical, high-scoring stem-loop structures and collectively display patterns of nucleotide divergence characteristic of genuine miRNAs (preponderance of divergence within the loop, slightly less divergence along a nonconserved arm, and perfect conservation of a putative miRNA-encoding arm) (Figure 6).
Rec12 (Spo11) protein shares homology with the catalytic (Top6A) subunit of Topoisomerase VI, which functions as a heterotetramer with Top6B [ 16 17 ] . However, no Top6B homolog is present in most eukaryotes and the Rec12 (Spo11) enzyme does not need to affect strand passage in the manner of canonical type II topoisomerases [ 11 ] . We therefore tested whether overexpression of rec12 +would lead to a hyper-recombination phenotype, thereby implicating function as a homodimer.
The physical resemblance to the canonical stem-loop precursor was also assessed with metrics that reward continuous helical pairing and progressively penalize internal loops of increasing size.
Using either the YL-1 or TMOD4 cDNAs in a BLAST search of the human EST database, we were unable to identify any additional intergenic transcripts, but we did uncover several YL-1 ESTs that had apparently spliced within exons in such a way as to not use the canonical consensus splice acceptors or donors, the rarer GC or AT donor sites or the AC acceptor site [ 29 ] . ESTs AI560960 and AI369608 were identical and contained YL-1 exons 1 and 2 but splice within exon 2 at position 276 (position is in bp relative to Genbank sequence D43642) to position 1107 (internal to exon 6) (Fig.
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