Example sentences for: canonical

How can you use “canonical” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The canonical thymidylate synthase (TS), such as the E. coli ThyA, is a protein with a distinct α/β-fold that transfers a methyl group to dUMP from 5,10-methylenetetrahydrofolate [ 29].

  • β-catenin nuclear translocation was detected in a subset of hippocampal, cortical and cerebellar neurons normally lacking nuclear protein, consistent with activation of the canonical Wnt pathway in these cells.

  • Juxtaposition of the two pentamers of ZAS-N forms a sequence homologous to the canonical RSS nonamer, "GGTTTTTGT".

  • We had previously shown by methylation interference analysis that KRC/ZAS-C bound specifically to the sequence TGTGG within the context of the canonical RSS heptamer plus the immediately flanking guanine [ 14 ] . Because the pentamer motif for KRC/ZAS-C predicted by MEME completely matched with the empirical results, we conclude that the two pentameric motifs discovered by MEME are likely authentic binding sites for KRC/ZAS-N as well.

  • With the exception of the conserved canonical GU and AG at the 5' and 3' splice sites, splice site sequences may contain several deviations from the consensus.


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