Words similar to camp-mediated
Example sentences for: camp-mediated
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3. Overexpression of USF2, but not USF1, inhibits cAMP-mediated and C/EBPβ-mediated induction of the RIIβ promoter.
C/EBP is previously reported to be an important accessory factor for transactivation by several other transcription factors [ 26 ] . C/EBPβ was shown to transactivate the α1-acid glycoprotein gene promoter even when mutated in the DNA-binding domain, and this activation appeared to depend on protein-protein interaction with glucocorticoid receptor through the leucine zipper region [ 27 ] . Recently, a conserved domain in C/EBPα and C/EBPβ was shown to mediate cAMP responsiveness, strengthening the fact that C/EBP may be characterized as a cAMP-responsive nuclear regulator [ 28 29 ] . On the COX-2 promoter in granulosa cells, cAMP-mediated regulation was shown to be mediated primarily by an E-box that bind USF1 and USF2 isoforms in a manner resembling the RIIβ E-box in Sertoli cells [ 30 ] . Transactivation of the COX-2 gene in skin carcinoma cells is highly dependent on this E-box together with a C/EBP binding site that bind C/EBPβ and C/EBPδ [ 31 ] . These data strengthens a model of formation of a cAMP-responsive unit (CRU) containing USF and C/EBP.
We have previously reported that some of the late induction of RIIβ by cAMP depends on the rapid cAMP-mediated increase in C/EBPβ expression [ 17 ] . To test the effect of different USF isoforms on C/EBPβ-mediated induction of the RIIβ promoter, we transfected combinations of the transcription factors (Fig.
As CD8 gene transcription has been turned-off by cAMP-mediated signaling, surface CD8 subsequently fades with the concomitant emergence of CD4+ cells.
USF2 inhibits cAMP-mediated induction of the RIIβ promoter
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