Words similar to calmodulin-dependent
Example sentences for: calmodulin-dependent
How can you use “calmodulin-dependent” in a sentence? Here are some example sentences to help you improve your vocabulary:
NMDA, N-methyl-D-aspartate; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; GluR, glutamate receptor; SPM, crude synaptic membrane; CaMKII, calcium/calmodulin-dependent protein kinase II; SDS PAGE, sodium dodecyl sulfate electrophoresis.
Thus—through functional genomics—calcineurin, calmodulin-dependent kinase, PGC-1α, and activated PPARδ form the basis of a signaling network that controls skeletal muscle fiber-type transformation and metabolic profiles that protect against insulin resistance and obesity.
cPLA 2 is phosphorylated by mitogen activated protein (MAP) kinases, including p42/p44 ERKs and p38, on Ser 505in vitro [ 16 17 ] and in response to receptor stimulation [ 16 18 19 20 21 ] . In addition to phosphorylation by MAP kinase, it has been shown that cPLA 2 is also phosphorylated on Ser 727by MAPK-interacting kinase I (MNKI) [ 22 ] and on Ser 515by calcium/calmodulin-dependent protein kinase II [ 23 ] . Phosphorylation of these sites may also play a role in regulating cPLA 2 function in certain cell models.
At least eight potential serine and threonine phosphorylation sites are present in the human protein involving such kinases as casein kinase I and II, protein kinase A and C, glycogen synthase kinase 3 and calmodulin-dependent protein kinase II (Figure 2).
The expressed 5-HT 2C receptor exhibits homologous and heterologous desensitization in oocytes [ 32 ] mediated by protein kinase C [ 33 34 35 ] . A calmodulin-dependent kinase may also be involved in homologous desensitization [ 36 ] . In contrast, a recent study indicates that neither PKC nor calmodulin-dependent protein kinase II are involved, instead desensitization of the 5-HT 2C receptor is dependent on GRK activity [ 37 ] . Interestingly, tyrosine kinase involvement in the agonist-mediated phosphorylation of the rat 5-HT 2C receptor has also been reported [ 38 ] , although as yet no report has shown that the 5-HT 2C receptor directly activates tyrosine kinases.
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