Words similar to caldesmon
Example sentences for: caldesmon
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We assayed the contents of some thin filament binding proteins, proposed to play roles in modulation of the actin-myosin coupling, e.g. calponin, caldesmon, and TM.
mesenteric circulation) demonstrate differences in the expression levels of six major contractile and thin filament-binding proteins, i.e. actin, myosin heavy chain (MHC), myosin light chain (MLC), tropomyosin (TM), calponin, and caldesmon.
Screening of the translated non-redundant database at GenBank with the amino acid sequence of the yeast D/E-rich domain selected numerous other aspartate-glutamate rich proteins, including neurofilament proteins and caldesmon.
Caldesmon is likely to play a modulatory role on the production of smooth muscle force via a tethering of actin to myosin [ 11 ] and/or of its effects on the actomyosin ATPase [ 12 13 14 ] . Similarly, TM does not seem to function as a major regulatory protein, but modulatory effects due to its ability to maintain the actin filamentous structure [ 15 ] , to inhibit the Ca 2+-ATPase activity [ 16 ] , alter the cytoskeletal dynamics [ 17 ] and improve actin filament flexibility during the contraction/relaxation cycle [ 18 19 ] have been well documented.
Moreover, it has been recognized that caldesmon and TM can modulate the actin-myosin interaction in a cooperative manner [ 20 ] , suggesting that functional effects of these proteins on actin-myosin coupling and smooth muscle mechanics ought to be interpreted in parallel.