Words similar to caldesmon
Example sentences for: caldesmon
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There were significant differences in the content of caldesmon.
The high molecular weight caldesmon (h-caldesmon) is the major isoform of intact vascular smooth muscle [ 7 ] . On the Western blots h-caldesmon appeared as a single band with apparent molecular weight of 130 kDa, which comigrated with h-caldesmon standard, purified from porcine stomach [ 8 ] . Densitometry of immunoreactive bands revealed that the artery contained approximately 1.39 times more h-caldesmon than vein (Fig.
For example, phasic and tonic behavior of gastrointestinal smooth muscles has been attributed to different expression levels of caldesmon and caldesmon-binding proteins, but not to differences in the relative proportions of myosin, actin, calponin, and tropomyosin [ 1 2 ] . Arteries and veins of different vascular beds are primarily composed of tonic smooth muscles.
Caldesmon is likely to play a modulatory role on the production of smooth muscle force via a tethering of actin to myosin [ 11 ] and/or of its effects on the actomyosin ATPase [ 12 13 14 ] . Similarly, TM does not seem to function as a major regulatory protein, but modulatory effects due to its ability to maintain the actin filamentous structure [ 15 ] , to inhibit the Ca 2+-ATPase activity [ 16 ] , alter the cytoskeletal dynamics [ 17 ] and improve actin filament flexibility during the contraction/relaxation cycle [ 18 19 ] have been well documented.
Moreover, it has been recognized that caldesmon and TM can modulate the actin-myosin interaction in a cooperative manner [ 20 ] , suggesting that functional effects of these proteins on actin-myosin coupling and smooth muscle mechanics ought to be interpreted in parallel.
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