Words similar to c-dvh
Example sentences for: c-dvh
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The authors are aware of the recent efforts regarding advanced modeling concepts for evaluating the relationship between physical irradiation and biological damage on normal structures - in particular, BED provides a measure of biological effect at a point at which it is calculated - measuring the absolute biological effect over a volume having a non-uniform dose distribution formally requires the computation of the equivalent uniform dose (EUD) [ 23 ] . However, this caveat does not apply directly to the current task, because the goal of the current investigation is to use the DVH (constructed using either conventional dose or BED) as a relative measure of biological response, not as an absolute measure, and in this context constructing a DVH from BED computations and averaging the DVH's (both C-DVH's and BED-DVH's) over a patient population was felt to be an appropriate methodology.
Equation (2) was applied to compute the δ AUC 's (both for the C-DVH's and for the BED-DVH's) for each of the six matched-patient pairs in the rectal toxicity category and to each of the six matched-patient pairs in the bladder toxicity category.
It should be noted that when applying Equation (3) to the BED-DVH's, the 60 Gy conventional dose transforms [using Equation (1), assuming once-daily 2 Gy fractions] to approximately 100 Gy; thus, V60 on the C-DVH's corresponds to V100 on the BED-DVH's.
The values for δ AUC and δ V60 are higher for the BED-DVH's of the rectum and bladder than for the counterpart C-DVH's.
Then, in a process similar to that for the C-DVH's, the BED-DVH's derived from each of the individual dose distributions were averaged over the six patients in each of the four groups (grade 0 - rectal, grade 3 - rectal, grade 0 - bladder, and grade 3 - bladder) to produce average BED-DVH's.
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