Example sentences for: bryostatin

How can you use “bryostatin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The potentiating effect of Bryostatin first becomes noticeable at 1 ng/ml and then reaches a plateau at 10-100 ng/ml.

  • Bryostatin 1 is a potent PKC activator that has undergone extensive clinical testing for the treatment of hematological malignancies and solid tumors [ 27 ] . Animal studies show that the concentration of Bryostatin 1 in various tissues after a single intraveneous injection stays in a range of 10-50 ng/g for a period of more than 72 hr [ 28 ] .

  • This proposal is supported by recent evidence that either genetic modification of ADAM-10/α-secretase activity [67] or administration of bryostatin, a PKC activator [68], can modulate levels of brain Aβ in plaque-forming transgenic mice.

  • At low concentration of IFNg (10 2IU/ml), the effect of Bryostatin was comparable to that of PMA.

  • However, if clinically tested PKC agonists such as Bryostatin 1 are able to rescue the IFNg-induced MHCII expression within the tumor bed, it might be appropriate to consider them for trials to improve the clinical efficacy of cancer immunotherapy.


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