Example sentences for: bryostatin

How can you use “bryostatin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Data, plotted in Figure 7, demonstrate that 10 ng/ml Bryostatin added into the culture medium containing 10 2-10 3IU/ml IFNg induced a 5- to 6-fold increase in levels of MHCII expression.

  • At low concentration of IFNg (10 2IU/ml), the effect of Bryostatin was comparable to that of PMA.

  • Bryostatin 1 may be considered for further investigation of IFNg-dependent MHCII induction in resistant tumors in vivo .

  • This may suggest that either the two PKC activators act through different isoforms of PKC or PMA also activates enzymes outside the PKC family such as MAPK [ 18 ] . Whatever the mechanism, it appears possible to restore the IFNg-dependent MHCII expression in LS1034 cell line by clinically acceptable concentrations of Bryostatin 1.

  • However, if clinically tested PKC agonists such as Bryostatin 1 are able to rescue the IFNg-induced MHCII expression within the tumor bed, it might be appropriate to consider them for trials to improve the clinical efficacy of cancer immunotherapy.


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