Words similar to bryostatin

Example sentences for: bryostatin

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At low concentration of IFNg (10 2IU/ml), the effect of Bryostatin was comparable to that of PMA.
The effect of PKC activators PMA and Bryostatin 1 on IFNg inducibility of MHCII in three resistant tumor cell lines of different histological origin has been examined.
Data, plotted in Figure 7, demonstrate that 10 ng/ml Bryostatin added into the culture medium containing 10 2-10 3IU/ml IFNg induced a 5- to 6-fold increase in levels of MHCII expression.
Bryostatin 1 is a potent PKC activator that has undergone extensive clinical testing for the treatment of hematological malignancies and solid tumors [ 27 ] . Animal studies show that the concentration of Bryostatin 1 in various tissues after a single intraveneous injection stays in a range of 10-50 ng/g for a period of more than 72 hr [ 28 ] .
This proposal is supported by recent evidence that either genetic modification of ADAM-10/α-secretase activity [67] or administration of bryostatin, a PKC activator [68], can modulate levels of brain Aβ in plaque-forming transgenic mice.