Words similar to bryostatin

Example sentences for: bryostatin

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Bryostatin 1 is a potent PKC activator that has undergone extensive clinical testing for the treatment of hematological malignancies and solid tumors [ 27 ] . Animal studies show that the concentration of Bryostatin 1 in various tissues after a single intraveneous injection stays in a range of 10-50 ng/g for a period of more than 72 hr [ 28 ] .
We also show that the IFNg-dependent MHCII expression in LS1034 cell line can be rescued by clinically acceptable concentrations of Bryostatin 1.
The effect of PKC activators PMA and Bryostatin 1 on IFNg inducibility of MHCII in three resistant tumor cell lines of different histological origin has been examined.
This proposal is supported by recent evidence that either genetic modification of ADAM-10/α-secretase activity [67] or administration of bryostatin, a PKC activator [68], can modulate levels of brain Aβ in plaque-forming transgenic mice.
Bryostatin 1 may be considered for further investigation of IFNg-dependent MHCII induction in resistant tumors in vivo .