Words similar to bryostatin

Example sentences for: bryostatin

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The effect of PKC activators PMA and Bryostatin 1 on IFNg inducibility of MHCII in three resistant tumor cell lines of different histological origin has been examined.
This may suggest that either the two PKC activators act through different isoforms of PKC or PMA also activates enzymes outside the PKC family such as MAPK [ 18 ] . Whatever the mechanism, it appears possible to restore the IFNg-dependent MHCII expression in LS1034 cell line by clinically acceptable concentrations of Bryostatin 1.
Bryostatin 1 may be considered for further investigation of IFNg-dependent MHCII induction in resistant tumors in vivo .
This proposal is supported by recent evidence that either genetic modification of ADAM-10/α-secretase activity [67] or administration of bryostatin, a PKC activator [68], can modulate levels of brain Aβ in plaque-forming transgenic mice.
Data, plotted in Figure 7, demonstrate that 10 ng/ml Bryostatin added into the culture medium containing 10 2-10 3IU/ml IFNg induced a 5- to 6-fold increase in levels of MHCII expression.