Words similar to bryostatin

Example sentences for: bryostatin

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The potentiating effect of Bryostatin first becomes noticeable at 1 ng/ml and then reaches a plateau at 10-100 ng/ml.
This may suggest that either the two PKC activators act through different isoforms of PKC or PMA also activates enzymes outside the PKC family such as MAPK [ 18 ] . Whatever the mechanism, it appears possible to restore the IFNg-dependent MHCII expression in LS1034 cell line by clinically acceptable concentrations of Bryostatin 1.
Bryostatin 1 is a potent PKC activator that has undergone extensive clinical testing for the treatment of hematological malignancies and solid tumors [ 27 ] . Animal studies show that the concentration of Bryostatin 1 in various tissues after a single intraveneous injection stays in a range of 10-50 ng/g for a period of more than 72 hr [ 28 ] .
The effect of PKC activators PMA and Bryostatin 1 on IFNg inducibility of MHCII in three resistant tumor cell lines of different histological origin has been examined.
Bryostatin 1 rescues IFNg inducibility of MHCII in LS1034 colon carcinoma cells