Example sentences for: brn

How can you use “brn” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Importantly, the spatio-temporal loss of innervation does not follow the pattern of loss known from neurotrophin and neurotrophin receptor null mutations as it starts in Brn3c mutant mice after birth.

  • Probing for the proper expression of supporting cell specific markers in Brn3c null mutants is necessary to further evaluate these suggestions.

  • Despite this reduction, some, apparently biologically significant low levels of neurotrophins are apparently expressed in all sensory epithelia in embryonic Brn3c null mutants.

  • Data on various single and compound neurotrophin null mutants have shown that the loss of a specific neurotrophin leads to topologically restricted loss of sensory neurons in the embryonic ear [ 4 5 ] . Such selective loss in Brn3c null mutants would therefore indicate reduction of a specific neurotrophin in immature hair cells.

  • In fact, an investigation of Brn3c heterozygotic mice showed no additional effect on hearing loss due to haploinsufficiency in these mice [ 35 ] . Our data on Brn3c null mouse mutants nevertheless suggest that the high to low frequency progressive hearing loss in humans may correlate with the unknown factor(s) that mediate apical spiral neuron survival into adulthood.


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