Words similar to breakage
Example sentences for: breakage
How can you use “breakage” in a sentence? Here are some example sentences to help you improve your vocabulary:
In Escherichia coli , spontaneous breakage and degradation of the chromosome associated with a replication fork were predicted from early genetic analysis and were detected under various conditions of altered replication (for review, see [ 5 ] ). DNA ds breaks play a key role in homologous recombination.
This may indicate breakage and rejoining events or tangled telomeres.
These interpretations are based on a previous work with a yeast circular chromosome and on our analysis of E. coli chromosomal breakage after loss of restriction-modification genes [ 3 15 16 ] . In this work, we focus on the second DNA species - the huge linear forms in the area just below the well (Figure 1, marked by the bar).
Tetrahymena telomerase and the binder/cutter appear to act concertedly in vivo , as if in a physical complex [ 48 49 ] . However, this contrasts with in vitro properties of the enzyme from exconjugants: 1.) it acts on non-telomeric primers [ 44 50 ] , and 2.) it apparently is no larger than the vegetative enzyme [ 44 ] . Furthermore, telomerase can act in the vegetative MAC of Paramecium , uncoupled from chromatid breakage [ 51 ] . It remains to be seen if a complex between telomerase and binder/cutter activity does exist.
The accumulation of the non-circular, broken chromosomes correlated with the growth rate or DNA damage response in most of the recBC -minus background [ 30 ] . The recB or recC null mutation showed low viability even in the absence of exogenous DNA damage [ 31 32 ] . A simple interpretation of these data is that RecA, RecFOR, and RecQJ functions (and RecET functions for the sbcA background) repair chromosome breakage and/or prevent generation of the breakage.
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