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Example sentences for: brachyury

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The history of the T locus began with the discovery in 1927 of a semi-dominant mutation in mice, named Brachyury , or T for tail, that affects both embryonic viability in homozygotes and tail development in heterozygotes [ 1 ] . This original T allele represents a deletion spanning 160-200 kb (reviewed in [ 2 ] ), the developmental effects of which have been well characterized [ 3 4 5 6 7 8 ] . Homozygous mutant embryos show a developmental failure of the notochord and posterior mesoderm, and die at midgestation.
In 1988, another spontaneous Brachyury mutation, called T Wis , was reported [ 9 ] . The T Wis homozygous and heterozygous mutant phenotypes are more severe than those of the T deletion, suggesting that the T Wis allele acts as a dominant negative.
The National Center for Biotechnology Information (www.ncbi.nlm.nih.gov/) accession numbers for the genes and gene products discussed in this paper are brachyury (AF012130), Cdx1 (NM_000209),
[ 10 ] evaluated peri-implantation gene expression profiles for 17α-hydroxylase, aromatase, brachyury and leukemia inhibitory factor receptor, all of which are more greatly expressed in filamentous conceptuses.
However, we did not detect expression of known markers of mesoderm formation, including brachyury, flk-1, myosin light chain-2, and β-globin, at any stage in our cultures (see Figure 1B).