Words similar to brachyury

Example sentences for: brachyury

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In 1988, another spontaneous Brachyury mutation, called T Wis , was reported [ 9 ] . The T Wis homozygous and heterozygous mutant phenotypes are more severe than those of the T deletion, suggesting that the T Wis allele acts as a dominant negative.
However, we did not detect expression of known markers of mesoderm formation, including brachyury, flk-1, myosin light chain-2, and β-globin, at any stage in our cultures (see Figure 1B).
The history of the T locus began with the discovery in 1927 of a semi-dominant mutation in mice, named Brachyury , or T for tail, that affects both embryonic viability in homozygotes and tail development in heterozygotes [ 1 ] . This original T allele represents a deletion spanning 160-200 kb (reviewed in [ 2 ] ), the developmental effects of which have been well characterized [ 3 4 5 6 7 8 ] . Homozygous mutant embryos show a developmental failure of the notochord and posterior mesoderm, and die at midgestation.
The National Center for Biotechnology Information (www.ncbi.nlm.nih.gov/) accession numbers for the genes and gene products discussed in this paper are brachyury (AF012130), Cdx1 (NM_000209),
[ 10 ] evaluated peri-implantation gene expression profiles for 17α-hydroxylase, aromatase, brachyury and leukemia inhibitory factor receptor, all of which are more greatly expressed in filamentous conceptuses.